Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease
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DOI: 10.1007/s12072-021-10200-y
Abstract: Several single-nucleotide polymorphisms have been identified to be disadvantageous or protective in regard to disease severity in patients with non-alcoholic fatty liver disease (NAFLD). However, it is unclear, whether including genetic risk factor(s) either alone… read more here.
Keywords: fibrosis; disease; liver; severity ... See more keywords
Impact of HSD17B13 rs72613567 genotype on hepatic decompensation and mortality in patients with portal hypertension
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DOI: 10.1111/liv.14304
Abstract: The loss‐of‐function rs72613567 T > TA‐variant in the 17β‐hydroxysteroid dehydrogenase 13 (HSD17B13) gene might protect from alcoholic and non‐alcoholic fatty liver disease (ALD/NAFLD) and associated fibrosis/cirrhosis. We investigated the impact of the T > TA‐variant… read more here.
Keywords: hepatic decompensation; impact; decompensation mortality; rs72613567 ... See more keywords
Fatty liver disease genetic risk variants and interference on sex hormones
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DOI: 10.1111/liv.15562
Abstract: Nonalcoholic fatty liver disease (NAFLD), also defined as metabolic dysfunctionassociated fatty liver disease (MAFLD),1 is the leading cause of chronic liver disease worldwide, accounting for up to 30% based on recent global estimates.2 NAFLD comprises… read more here.
Keywords: disease; hsd17b13; sex; risk ... See more keywords
Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients
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DOI: 10.1155/2020/4216451
Abstract: A single-nucleotide polymorphism causing a C to G change in the PNPLA3 gene (rs738409) is associated with disease severity and development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease; the insertion variant rs72613567:TA of… read more here.
Keywords: risk; hcc; hepatitis; hsd17b13 ... See more keywords
Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
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DOI: 10.3390/ijms231911840
Abstract: A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced fibrosis and… read more here.
Keywords: decompensation; variant hsd17b13; cirrhotic patients; hsd17b13 ... See more keywords
MTARC1 and HSD17B13 Variants Have Protective Effects on Non-Alcoholic Fatty Liver Disease in Patients Undergoing Bariatric Surgery
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DOI: 10.3390/ijms232415825
Abstract: The severity of hepatic steatosis is modulated by genetic variants, such as patatin-like phospholipase domain containing 3 (PNPLA3) rs738409, transmembrane 6 superfamily member 2 (TM6SF2) rs58542926, and membrane-bound O-acyltransferase domain containing 7 (MBOAT7) rs641738. Recently,… read more here.
Keywords: liver; hsd17b13; mtarc1; hepatic steatosis ... See more keywords