Aldosterone-sensitive HSD2 neurons in mice
Sign Up to like & getrecommendations! Published in 2018 at "Brain Structure and Function"
DOI: 10.1007/s00429-018-1778-y
Abstract: Sodium deficiency elevates aldosterone, which in addition to epithelial tissues acts on the brain to promote dysphoric symptoms and salt intake. Aldosterone boosts the activity of neurons that express 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2), a… read more here.
Keywords: sensitive hsd2; hsd2 neurons; hsd2; aldosterone sensitive ... See more keywords
Sex-specific and lasting effects of a single course of antenatal betamethasone treatment on human placental 11β-HSD2.
Sign Up to like & getrecommendations! Published in 2018 at "Placenta"
DOI: 10.1016/j.placenta.2018.07.007
Abstract: INTRODUCTION We have previously shown that even a single course of antenatal betamethasone (BET) as an inductor for lung maturity reduces birth weight and head circumference. Moreover, animal studies link BET administration to alterations of… read more here.
Keywords: antenatal betamethasone; hsd2; course antenatal; sex ... See more keywords
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.6b00950
Abstract: 17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the active steroid hormones estradiol, testosterone, and 5α-dihydrotestosterone into their weakly active forms estrone, Δ4-androstene-3,17-dione, and 5α-androstane-3,17-dione, respectively, thereby regulating cell- and tissue-specific steroid action. As reduced levels of… read more here.
Keywords: ic50; hydroxysteroid dehydrogenase; hsd2; dehydrogenase type ... See more keywords
Association among placental 11β‐HSD2, PPAR‐γ, and NF‐κB p65 in small‐for‐gestational‐age infants: A nested case‐control study
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13231
Abstract: 11β‐Hydroxysteroid dehydrogenase 2 (11β‐HSD2) catalyzes active glucocorticoids into their inactive products, preventing the passage of glucocorticoids into the fetus from maternal circulation. Peroxisome proliferator‐activated receptor (PPAR)γ is a member of the nuclear receptor superfamily that… read more here.
Keywords: ppar; ppar p65; hsd2; association among ... See more keywords
OR10-1 Regulation of Glucocorticoid Metabolism: A Novel Function for Thyroid Hormones?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-or10-1
Abstract: Abstract Glucocorticoid hormone metabolism and action are regulated by the 11-beta hydroxysteroid dehydrogenase (11βHSD) isozymes: the 11βHSD2, mostly expressed in the distal nephron, converts cortisol [F] into cortisone [E] in humans or corticosterone [B] into… read more here.
Keywords: activity; metabolism; hsd2; thyroid hormones ... See more keywords
Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.867073
Abstract: Background 3β-hydroxysteroid dehydrogenase 2 (3βHSD2) deficiency is a rare form of congenital adrenal hyperplasia (CAH), with fewer than 200 cases reported in the world literature and few data on outcomes. Patients and Methods We report… read more here.
Keywords: hsd2; hydroxysteroid dehydrogenase; deficiency; deficiency algeria ... See more keywords
Antifibrotic Effect of a Novel Selective 11β-HSD2 Inhibitor (WZ51) in a rat Model of Myocardial Fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.629818
Abstract: Myocardial fibrosis (MF) is one of the leading causes of end-stage heart disease. Many studies have confirmed that inflammation caused by aldosterone may play an important role in the process of MF. A selective 11β-hydroxysteroid… read more here.
Keywords: selective hsd2; inhibitor; effect novel; hsd2 ... See more keywords
Maternal High-Fructose Corn Syrup Intake Impairs Corticosterone Clearance by Reducing Renal 11β-Hsd2 Activity via miR-27a-Mediated Mechanism in Rat Offspring
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15092122
Abstract: We previously reported that maternal fructose consumption increases blood corticosterone levels in rat offspring. However, the underlying mechanism of action remains unclear. In the present study, we aimed to elucidate the molecular mechanism by which… read more here.
Keywords: rat offspring; mechanism; hsd2; mir 27a ... See more keywords