Germline Variant in HSD3B1 (1245 A > C) and Response to Abiraterone Acetate Plus Prednisone in Men With New‐Onset Metastatic Castration‐Resistant Prostate Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2018.03.006
Abstract: Micro‐Abstract The HSD3B1 (1245C) variant is predictive of response to ADT in castration sensitive prostate cancer (CSPC) and to ketoconazole in castration resistant prostate cancer (CRPC). We hypothesized that the HSD3B1 (1245C) variant would be… read more here.
Keywords: response; 1245c variant; prostate cancer; castration ... See more keywords
The association between HSD3B1 genotype and steroid metabolism in normal and prostate cancer (PCa) tissue.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.tps155
Abstract: TPS155Background: The common germline variant HSD3B1(1245C) encodes for a gain-of-function in 3βHSD1 which is associated with a shorter duration of response to androgen deprivation therapy (ADT) and more rapid disease progression to castration resistant PCa… read more here.
Keywords: genotype; tissue; hsd3b1; association hsd3b1 ... See more keywords