MED12 interacts with the heat‐shock transcription factor HSF1 and recruits CDK8 to promote the heat‐shock response in mammalian cells
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14139
Abstract: Activated and promoter‐bound heat‐shock transcription factor 1 (HSF1) induces RNA polymerase II recruitment upon heat shock, and this is facilitated by the core Mediator in Drosophila and yeast. Another Mediator module, CDK8 kinase module (CKM),… read more here.
Keywords: heat shock; shock transcription; hsf1; heat ... See more keywords
HSF1 activates the FOXO3a–ΔNp63α–CDK4 axis to promote head and neck squamous cell carcinoma cell proliferation and tumour growth
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14588
Abstract: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. Heat shock factor 1 (HSF1) is a conserved transcriptional factor that plays a critical role in maintaining cellular proteostasis. However,… read more here.
Keywords: cell; hsf1; tumour growth; head neck ... See more keywords
HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response
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DOI: 10.1002/2211-5463.12863
Abstract: The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cells. However,… read more here.
Keywords: response; induction mitochondrial; hsf1; mitochondrial unfolded ... See more keywords
The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03568-x
Abstract: Protein homeostasis is essential for life in eukaryotes. Organisms respond to proteotoxic stress by activating heat shock transcription factors (HSFs), which play important roles in cytoprotection, longevity and development. Of six human HSFs, HSF1 acts… read more here.
Keywords: transcription; hsf1; proteasome dysfunction; expression ... See more keywords
Quantitative Comparison of HSF1 Activators
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DOI: 10.1007/s12033-022-00467-3
Abstract: The heat shock response (HSR) pathway is a highly conserved rescue mechanism, which protects the cells from harmful insults disturbing the cellular protein homeostasis via expression of chaperones. Furthermore, it was demonstrated to play crucial… read more here.
Keywords: hsf1; quantitative comparison; hsf1 activators; comparison hsf1 ... See more keywords
Effects of radiofrequency field exposure on proteotoxic-induced and heat-induced HSF1 response in live cells using the bioluminescence resonance energy transfer technique
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01172-3
Abstract: As of today, only acute effects of RF fields have been confirmed to represent a potential health hazard and they are attributed to non-specific heating (≥ 1 °C) under high-level exposure. Yet, the possibility that environmental RF… read more here.
Keywords: live cells; hsf1; exposure; induced hsf1 ... See more keywords
Mechanism of miR-455–3 in suppressing epithelial–mesenchymal transition and angiogenesis of non-small cell lung cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-022-01254-4
Abstract: The tumor-suppressing role of miR-455-3p has been reported in lung cancer, but the working mechanism remains to be fully elucidated. This study aims to explore the possible mechanism of miR-455-3p in regulating epithelial–mesenchymal transition (EMT)… read more here.
Keywords: hsf1; gls1; angiogenesis; nsclc cells ... See more keywords
HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.08.039
Abstract: Considerable evidences have shown that both heat shock transcription factor 1 (HSF1) and autophagy can attenuate the sensitivity of hepatocellular carcinoma (HCC) cells to chemotherapeutic reagents. However, it is still little known whether HSF1 is… read more here.
Keywords: hepatocellular carcinoma; hsf1; hcc cells; autophagy ... See more keywords
Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity
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DOI: 10.1016/j.celrep.2018.02.083
Abstract: SUMMARY Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of… read more here.
Keywords: cell; hsf1 phosphorylation; hsf1; cell variation ... See more keywords
Rethinking HSF1 in Stress, Development, and Organismal Health.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.08.002
Abstract: The heat shock response (HSR) was originally discovered as a transcriptional response to elevated temperature shock and led to the identification of heat shock proteins and heat shock factor 1 (HSF1). Since then HSF1 has… read more here.
Keywords: hsf1; organismal health; stress; hsr ... See more keywords
Hsf1 on a leash - Controlling the heat shock response by chaperone titration.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112246
Abstract: Heat shock factor 1 (Hsf1) is an ancient transcription factor that monitors protein homeostasis (proteostasis) and counteracts disturbances by triggering a transcriptional programme known as the heat shock response (HSR). The HSR is transiently activated… read more here.
Keywords: heat shock; shock response; chaperone; hsf1 ... See more keywords