The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells.
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DOI: 10.1002/1873-3468.14617
Abstract: Upon heat shock, activated heat shock transcription factor 1 (HSF1) binds to the heat shock response elements (HSEs) in the promoters of mammalian heat shock protein (HSP)-encoding genes and recruits the preinitiation complex and coactivators,… read more here.
Keywords: hsf1 condensates; heat; shock response; heat shock ... See more keywords