Safety, pharmacokinetics and pharmacodynamics of a novel γ-aminobutyric acid (GABA) receptor potentiator, HSK3486, in Chinese patients with hepatic impairment
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DOI: 10.1080/07853890.2022.2129433
Abstract: Abstract Background The primary objective of this study was to investigate if hepatic impairment alters the safety, pharmacokinetics, and pharmacodynamics of HSK3486. Research design and methods This was a clinical trial of HSK3486 in subjects… read more here.
Keywords: hsk3486; mild moderate; hepatic impairment; safety pharmacokinetics ... See more keywords
Efficacy and safety of HSK3486 vs. propofol for the induction and maintenance of general anaesthesia: A multicentre, single-blind, randomised, parallel-group, phase 3 clinical trial.
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DOI: 10.1097/eja.0000000000001799
Abstract: BACKGROUND HSK3486 (ciprofol) is a 2,6-disubstituted phenol derivative that acts like propofol as an agonist at the gamma-aminobutyric acid-A (GABAA) receptor. OBJECTIVE To investigate the efficacy and safety of HSK3486 for general anaesthesia induction and… read more here.
Keywords: hsk3486; maintenance; trial; group ... See more keywords
Efficacy and safety of HSK3486 for the induction and maintenance of general anesthesia in elective surgical patients: a multicenter, randomized, open-label, propofol-controlled phase 2 clinical trial.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202202_28101
Abstract: OBJECTIVE To evaluate the efficacy and safety of HSK3486 for the induction and maintenance of general anesthesia in elective surgical patients, but excluding emergency, cardiothoracic, cerebral and endoscopic sinus cases. PATIENTS AND METHODS A total… read more here.
Keywords: hsk3486; maintenance general; maintenance; propofol ... See more keywords