Excision of uracil from DNA by hSMUG1 includes strand incision and processing
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1184
Abstract: Abstract Uracil arises in DNA by hydrolytic deamination of cytosine (C) and by erroneous incorporation of deoxyuridine monophosphate opposite adenine, where the former event is devastating by generation of C → thymine transitions. The base… read more here.
Keywords: uracil dna; strand incision; dna; excision ... See more keywords
The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil–DNA Glycosylase SMUG1
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DOI: 10.3390/molecules24173133
Abstract: Human SMUG1 (hSMUG1) hydrolyzes the N-glycosidic bond of uracil and some uracil lesions formed in the course of epigenetic regulation. Despite the functional importance of hSMUG1 in the DNA repair pathway, the damage recognition mechanism… read more here.
Keywords: site residues; dna; active site; phe98 his239 ... See more keywords