Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1915-y
Abstract: Motor neurons containing aggregates of superoxide dismutase 1 (SOD1) are hallmarks of amyotrophic lateral sclerosis (ALS) caused by mutations in the gene encoding SOD1. We have previously reported that two strains of mutant human (h)… read more here.
Keywords: seed; amyotrophic lateral; hsod1; superoxide dismutase ... See more keywords
α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.05.019
Abstract: Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA)… read more here.
Keywords: antioxidant; erk akt; pathway; hsod1 ... See more keywords
Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01032-2
Abstract: Increasing evidence suggests that propagation of the motor neuron disease amyotrophic lateral sclerosis (ALS) involves the pathogenic aggregation of disease-associated proteins that spread in a prion-like manner. We have identified two aggregate strains of human… read more here.
Keywords: seed; aggregation; disease; aggregate selective ... See more keywords