Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain
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DOI: 10.1002/pro.4126
Abstract: Hsp104, a yeast protein disaggregase, can be potentiated via numerous missense mutations at disparate locations throughout the coiled‐coil middle domain (MD). Potentiated Hsp104 variants can counter the toxicity and misfolding of TDP‐43, FUS, and α‐synuclein,… read more here.
Keywords: scanning mutagenesis; drivers hsp104; hsp104 potentiation; potentiation ... See more keywords