A curcumin analogue GO‐Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13550
Abstract: Cancer stem cells (CSCs) are proposed to be involved in tumor initiation and play important roles in cancer relapse, metastasis, and drug resistance. Therefore, the targeting of CSCs has potential for effective anticancer therapies. Curcumin… read more here.
Keywords: cancer stem; hsp40; y030; hsp70 hsp40 ... See more keywords
The roles of a flagellar HSP40 ensuring rhythmic beating
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DOI: 10.1091/mbc.e18-01-0047
Abstract: HSP40s are regarded as cochaperones, perpetually shuttling client polypeptides to HSP70s for refolding. However, many HSP40s that are central for disparate processes diverge from this paradigm. To elucidate the noncanonical mechanisms, we investigated HSP40 in… read more here.
Keywords: roles flagellar; flagellar hsp40; hsp40; biology ... See more keywords
Structural basis for client recognition and activity of Hsp40 chaperones
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DOI: 10.1126/science.aax1280
Abstract: Catch and release Chaperones are essential for proper protein folding inside cells, but their interactions with client proteins are difficult to study because they are dynamic. Jiang et al. used nuclear magnetic resonance spectroscopy to… read more here.
Keywords: protein; client; hsp40; hsp40 chaperones ... See more keywords
Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites
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DOI: 10.1128/mbio.00760-21
Abstract: During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts. Protein prenylation is required during asexual replication of Plasmodium falciparum, and the canonical heat shock protein 40 protein (HSP40;… read more here.
Keywords: hsp40; plasmodium falciparum; malaria; protein prenylation ... See more keywords
Analysis of the Interactome of the Toxoplasma gondii Tgj1 HSP40 Chaperone
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DOI: 10.3390/proteomes11010009
Abstract: Toxoplasma gondii is an obligate intracellular apicomplexan that causes toxoplasmosis in humans and animals. Central to its dissemination and pathogenicity is the ability to rapidly divide in the tachyzoite stage and infect any type of… read more here.
Keywords: cell; tgj1; hsp40; gondii ... See more keywords