Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801982
Abstract: Abstract Collagen is the most abundant structural protein in mammals and is crucial for the mechanical integrity of tissues. Hsp47, an endoplasmic reticulum resident collagen‐specific chaperone, is involved in collagen biosynthesis and plays a fundamental… read more here.
Keywords: collagen; secretion; hsp47 tool; hsp47 ... See more keywords
HSP47: a potential target for fibrotic diseases and implications for therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Expert opinion on therapeutic targets"
DOI: 10.1080/14728222.2021.1861249
Abstract: Introduction: Chronic fibrotic disorders are challenging clinical problems. The major challenge is the identification of specific targets expressed selectively in fibrotic tissues to avoid potential side effects of inhibiting ubiquitous factors in healthy tissues. Extensive… read more here.
Keywords: collagen; fibrotic diseases; fibrosis; target ... See more keywords
Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-04-779934
Abstract: Chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT) is characterized by multiorgan fibrosis and profoundly affects the quality of life of transplant survivors. Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone,… read more here.
Keywords: fibrosis; versus host; fibrosis chronic; hsp47 ... See more keywords
Aberrant binding of mutant HSP47 affects posttranslational modification of type I collagen and leads to osteogenesis imperfecta.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009339
Abstract: Heat shock protein 47 (HSP47), encoded by the SERPINH1 gene, is a molecular chaperone essential for correct folding of collagens. We report a homozygous p.(R222S) substitution in HSP47 in a child with severe osteogenesis imperfecta… read more here.
Keywords: collagen; osteogenesis imperfecta; hsp47; type collagen ... See more keywords
The Role of HSP47 in Thrombotic Disorders: Molecular Mechanism and Therapeutic Potential
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DOI: 10.3390/cimb47040283
Abstract: This review aims to analyze the role of heat shock protein 47 (HSP47) in thrombosis and evaluate its potential as a therapeutic target for deep vein thrombosis (DVT). A systematic literature review was conducted using… read more here.
Keywords: role hsp47; hsp47; role; collagen ... See more keywords
Low Expression of Selenoprotein S Modulates Osteogenic Differentiation Through Bidirectional Regulation of the SP7–HSP47/COL1A1/SPARC Axis
Sign Up to like & getrecommendations! Published in 2025 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb47090677
Abstract: Previous studies revealed that low expression of Selenoprotein S (SELS) could enhance osteogenic differentiation, but the underlying mechanisms remain unclear. In this study, we aimed to elucidate the role of SELS and its transcription-factor-based regulatory… read more here.
Keywords: hsp47; sp7; expression; osteogenic differentiation ... See more keywords