ER, Mitochondria, and ISR Regulation by mt‐HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201273
Abstract: Cellular response to protein misfolding underlies multiple diseases. Collagens are the most abundant vertebrate proteins, yet little is known about cellular response to misfolding of their procollagen precursors. Osteoblasts (OBs)—the cells that make bone—produce so… read more here.
Keywords: procollagen misfolding; hsp70 atf5; procollagen; response ... See more keywords
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer
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DOI: 10.1002/ijc.30918
Abstract: Mitochondrial mortalin and cytosolic Hsp70 are essential chaperones overexpressed in cancer cells. Our goals were to reproduce our earlier findings of elevated circulating levels of mortalin and Hsp70 in colorectal cancer (CRC) patients with a… read more here.
Keywords: risk; hsp70; mortalin hsp70; cea ca19 ... See more keywords
Pharmacological inhibition of BAG3-HSP70 with the proposed cancer therapeutic JG-98 is toxic for cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30140
Abstract: The co-chaperone Bcl2-associated athanogene-3 (BAG3) maintains cellular protein quality control through the regulation of heat shock protein 70 (HSP70). Cancer cells manipulate BAG3-HSP70-regulated pathways for tumor initiation and proliferation, which has led to the development… read more here.
Keywords: protein; bag3 hsp70; hsp70; microscopy ... See more keywords
TGF‐β and HSP70 profiles during transformation of yak hair follicles from the anagen to catagen stage
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28212
Abstract: Transforming growth factor‐β (TGF‐β) and heat shock protein 70 (HSP70) are important for the hair follicle (HF) cycle, but it is unclear whether they participate in HF regression in yak skin. In this study, we… read more here.
Keywords: hsp70; tgf rii; tgf; catagen ... See more keywords
Effect of evolution of the C‐terminal region on chaperone activity of Hsp70
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DOI: 10.1002/pro.4549
Abstract: Dynamic interdomain interactions within the Hsp70 protein is the basis for the allosteric and functional properties of Hsp70s. While Hsp70s are generally conserved in terms of structure, allosteric behavior, and some overlapping functions, Hsp70s also… read more here.
Keywords: hsp70 members; terminal region; region; chaperone activity ... See more keywords
Construction and application of an HSP70 promoter-inducible genome editing system in transgenic silkworm to induce resistance to Nosema bombycis
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10135-3
Abstract: The microsporidian Nosema bombycis is an obligate intracellular parasitic fungus that causes devastating disease in sericulture. To date, no efficient biotechnological method to inhibit the proliferation of microspores has been established. Here, we developed a… read more here.
Keywords: genome editing; hsp70; system; transgenic silkworm ... See more keywords
Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett’s esophagus
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05582-y
Abstract: The incidence of esophageal adenocarcinoma (EAC) has been increasing for decades without significant improvements in treatment. Barrett’s esophagus (BE) is best established risk factor for EAC, but current surveillance with random biopsies cannot predict progression… read more here.
Keywords: barrett esophagus; endoscopy; fluorescence molecular; hsp70 tpp ... See more keywords
Role of intestinal Hsp70 in barrier maintenance: contribution of milk to the induction of Hsp70.2
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Surgery International"
DOI: 10.1007/s00383-017-4211-3
Abstract: BackgroundNecrotizing enterocolitis (NEC) is a gastrointestinal disease of complex etiology resulting in devastating systemic inflammation and often death in premature newborns. We previously demonstrated that formula feeding inhibits ileal expression of heat shock protein-70 (Hsp70),… read more here.
Keywords: milk; protein; hsp70; barrier ... See more keywords
Effect of lignite fulvic acid on growth, antioxidant ability, and HSP70 of Pacific white shrimp, Litopenaeus vannamei
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture International"
DOI: 10.1007/s10499-018-0302-y
Abstract: This study was conducted to evaluate the effects of fulvic acid (0, 0.3, 0.6, 0.9, and 1.2%) as feed additive on growth, feed utilization, antioxidant ability, and HSP70 in hemolymph and hepatopancreas of juvenile white… read more here.
Keywords: hsp70; shrimp; fulvic acid; fed fulvic ... See more keywords
Co-enzyme Q10 and acetyl salicylic acid enhance Hsp70 expression in primary chicken myocardial cells to protect the cells during heat stress
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3058-1
Abstract: We investigated the effects of co-enzyme Q10 (Q10) and acetyl salicylic acid (ASA) on expression of Hsp70 in the protection of primary chicken myocardial cells during heat stress. Western blot analysis showed that Q10 and… read more here.
Keywords: hsf; hsp70; heat stress; expression ... See more keywords
Immunodetection of heat shock protein 70 and cell death in liver of a neotropical fish acutely and chronically exposed to acetaminophen and propranolol
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-11264-3
Abstract: The use of pharmaceutical drugs ends frequently in their inappropriate disposal and treatment at waste water treatment plants, which is the cause of their widespread presence in the environment. Yet, there is limited understanding or… read more here.
Keywords: chronically exposed; hsp70; heat shock; propranolol ... See more keywords