A curcumin analogue GO‐Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates
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DOI: 10.1002/2211-5463.13550
Abstract: Cancer stem cells (CSCs) are proposed to be involved in tumor initiation and play important roles in cancer relapse, metastasis, and drug resistance. Therefore, the targeting of CSCs has potential for effective anticancer therapies. Curcumin… read more here.
Keywords: cancer stem; hsp40; y030; hsp70 hsp40 ... See more keywords
Active unfolding of the glucocorticoid receptor by the Hsp70/Hsp40 chaperone system in single-molecule mechanical experiments
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119076119
Abstract: Significance One of the key unresolved questions in the field of molecular chaperones is how they can actively unfold proteins. In this study, we discovered that the Hsp70/Hsp40 chaperone system completely unfolds a native soluble… read more here.
Keywords: hsp70 hsp40; receptor; hsp70; hsp40 chaperone ... See more keywords
Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents
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DOI: 10.3390/ijms24044083
Abstract: A class of chaperones dubbed heat shock protein 70 (Hsp70) possesses high relevance in cancer diseases due to its cooperative activity with the well-established anticancer target Hsp90. However, Hsp70 is closely connected with a smaller… read more here.
Keywords: small molecule; molecule modulators; synthetic small; hsp70 hsp40 ... See more keywords
Modeling Hsp70/Hsp40 interaction by multi-scale molecular simulations and coevolutionary sequence analysis
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DOI: 10.7554/elife.23471
Abstract: The interaction between the Heat Shock Proteins 70 and 40 is at the core of the ATPase regulation of the chaperone machinery that maintains protein homeostasis. However, the structural details of the interaction remain elusive… read more here.
Keywords: molecular simulations; interaction; sequence analysis; coevolutionary sequence ... See more keywords