Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti–PD-1 immunotherapy
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DOI: 10.1126/scitranslmed.abq7019
Abstract: The tumor-intrinsic NOD-, LRR- and pyrin domain-containing protein-3 (NLRP3) inflammasome–heat shock protein 70 (HSP70) signaling axis is triggered by CD8+ T cell cytotoxicity and contributes to the development of adaptive resistance to anti–programmed cell death… read more here.
Keywords: anti immunotherapy; hsp70 tlr4; hyperprogression; tumor ... See more keywords