Hsp72 Is an Intracellular Target of the α,β-Unsaturated Sesquiterpene Lactone, Parthenolide
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DOI: 10.1021/acsomega.7b00954
Abstract: The electrophilic natural product parthenolide has generated significant interest as a model for potential chemotherapeutics. Similar to other α,β-unsaturated carbonyl electrophiles, parthenolide induces the heat shock response in leukemia cells, potentially through covalent adduction of… read more here.
Keywords: heat shock; parthenolide; parthenolide derivative; hsp72 ... See more keywords
Neutron crystallographic analysis of the nucleotide-binding domain of Hsp72 in complex with ADP
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DOI: 10.1107/s2052252522006297
Abstract: The neutron crystallographic structure of an Hsp72–ADP complex is reported. read more here.
Keywords: crystallographic analysis; hsp72; nucleotide binding; analysis nucleotide ... See more keywords
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao2464
Abstract: Phosphorylation uncouples the functions of the chaperone Hsp72 during mitosis. Modified Hsp72 structure-function in mitosis Chaperone proteins support protein folding, mediate the formation of multiprotein complexes, and enable protein degradation. The functions of the chaperone… read more here.
Keywords: binding substrate; hsp72; atp binding; phosphorylation ... See more keywords
Intrapulmonary Autoantibodies to HSP72 Are Associated with Improved Outcomes in IPF
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/1845128
Abstract: Rationale Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease, with high mortality. Currently, the aetiology and the pathology of IPF are poorly understood, with both innate and adaptive responses previously being implicated… read more here.
Keywords: outcomes ipf; hsp72; disease; improved outcomes ... See more keywords