Hsp90β-Selective Inhibitors: Probing the Solvent-Accessible Frontier.
Sign Up to like & getrecommendations! Published in 2025 at "ChemMedChem"
DOI: 10.1002/cmdc.202500657
Abstract: Inhibitors of the 90‐ kDa heat shock protein (Hsp90) family, especially Hsp90β, have been a sought‐after therapeutic strategy for the treatment of cancer, neurological disorders, and other diseases. Furthermore, recent studies suggest that their coadministration with… read more here.
Keywords: inhibitors probing; selective inhibitors; probing solvent; hsp90 ... See more keywords
HSP90 Inhibition Drives Degradation of FGFR2 Fusion Proteins: Implications for Treatment of Cholangiocarcinoma
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DOI: 10.1002/hep.30127
Abstract: About 15% of intrahepatic cholangiocarcinomas (ICCs) express constitutively active fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs) generated by chromosomal translocations. FFs have been nominated as oncogenic drivers because administration of FGFR tyrosine kinase… read more here.
Keywords: hsp90; fusion proteins; fgfr2 fusion; bgj398 ... See more keywords
Near Infrared-Triggered Theranostic Nanoplatform with Controlled Release of HSP90 Inhibitor for Synergistic Mild Photothermal and Enhanced Nanocatalytic Therapy with Hypoxia Relief.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202200786
Abstract: Mild photothermal therapy (PTT, 50 °C). However, its therapeutic efficacy is limited owing to the hypoxic tumor environment and tumor thermoresistance owing to the overproduction of heat shock proteins (HSPs). Herein, a near-infrared (NIR)-triggered theranostic nanoplatform… read more here.
Keywords: hsp90; therapy; triggered theranostic; mild photothermal ... See more keywords
Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7477-1_28
Abstract: Molecular chaperones are a diverse group of highly conserved proteins that transiently interact with partially folded polypeptide chains during normal cellular processes such as protein translation, translocation, and disassembly of protein complexes. Prior to folding… read more here.
Keywords: protein; hsp90; chaperones regulating; evidence hsp90 ... See more keywords
Hsp90 inhibition sensitizes DLBCL cells to cisplatin
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-022-04407-5
Abstract: Platinum-containing therapy is standard treatment for relapsed Diffuse Large B-Cell Lymphoma (DLBCL). However, the efficacy of treatment is limited by drug resistance leading to relapse. Cisplatin resistance has been linked to impairments of the DNA… read more here.
Keywords: dlbcl cells; hsp90; combination; cells cisplatin ... See more keywords
Design, synthesis, and biological evaluation of 4-(1H-1,2,3-triazol-1-yl)benzamides as HSP90 inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular diversity"
DOI: 10.1007/s11030-022-10423-7
Abstract: Heat shock protein 90 (HSP90) is a promising anticancer drug target, which could be employed to construct HSP90 inhibitors-based drug conjugates for selective tumor therapy. Herein, a series of 4-(1H-1,2,3-triazol-1-yl)benzamides were rationally designed, synthesized as… read more here.
Keywords: synthesis biological; hsp90; design synthesis; triazol benzamides ... See more keywords
Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-018-0955-5
Abstract: The extracellular heat shock protein 90 (Hsp90) is known to participate in cell migration and invasion. Recently, we have shown that cell surface heparan sulfate proteoglycans (HSPGs) are involved in the binding and anchoring of… read more here.
Keywords: extracellular hsp90; hsp90; migration; cell ... See more keywords
Inhibition of Hsp90 K284 Acetylation Aalleviates Cardiac Injury After Ischemia–Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-024-10548-0
Abstract: Our objective was to determine the role of acetyl-Hsp90 and its relationship with the NF-κB p65 signaling pathway in CVDs. We investigated the effect of acetyl-Hsp90 on cardiac inflammation and apoptosis after ischemia–reperfusion injury (I/RI).… read more here.
Keywords: ischemia reperfusion; p65; reperfusion injury; injury ... See more keywords
Heat Shock Protein 90α Provides an Effective and Novel Diagnosis Strategy for Nasopharyngeal Carcinoma
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DOI: 10.1007/s12325-020-01518-4
Abstract: Introduction Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated tumor occurring in southeastern Asia. Due to insidious onset, it is difficult to diagnose NPC from clinical symptoms. Thus, there is an urgent need for non-invasive,… read more here.
Keywords: heat shock; hsp90; shock protein; diagnosis ... See more keywords
Analysis of cellular models of clonal evolution reveals co-evolution of imatinib and HSP90 inhibitor resistances.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.059
Abstract: Treatment relapse due to clonal evolution was shown to be an independent factor for poor prognosis in advanced stages of chronic myeloid leukemia. Overcoming secondary resistance arising due to clonal evolution is still an unmet… read more here.
Keywords: clonal evolution; hsp90; inhibitor; evolution ... See more keywords
Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114097
Abstract: Idiopathic pulmonary fibrosis is a progressive-fibrosing lung disease with high mortality and limited therapy, which characterized by myofibroblasts proliferation and extracellular matrix deposition. Myricetin, a natural flavonoid, has been shown to possess a variety of… read more here.
Keywords: hsp90; induced pulmonary; pulmonary fibrosis; tgf signaling ... See more keywords