Structural and biochemical insights into FKBP51 as a Hsp90 co-chaperone.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30384
Abstract: The FK506-binding protein 51 (FKBP51) is a high-molecular-weight immunophilin that emerged as an important drug target for stress-related disorders, chronic pain, and obesity. It has been implicated in a plethora of molecular pathways but remains… read more here.
Keywords: fkbp51 hsp90; insights fkbp51; biochemical insights; chaperone ... See more keywords
Hsp90 Co‐chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.02.012
Abstract: HighlightsMitochondrial stress (MPP+) increases interaction between PHD2 and p23:Hsp90 chaperone complex.p23 inhibitor Gedunin prevents MPP+ mediated dopaminergic cell death via destabilization of PHD2‐P23‐HSP90 complex. ABSTRACT The heat shock factor 90 (hsp90) complex has long been… read more here.
Keywords: hsp90 chaperone; phd2; hsp90; stress ... See more keywords
Modulation of hippocampal neuronal resilience during aging by the Hsp70/Hsp90 co‐chaperone STI1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14882
Abstract: Chaperone networks are dysregulated with aging, but whether compromised Hsp70/Hsp90 chaperone function disturbs neuronal resilience is unknown. Stress‐inducible phosphoprotein 1 (STI1; STIP1; HOP) is a co‐chaperone that simultaneously interacts with Hsp70 and Hsp90, but whose… read more here.
Keywords: hsp90 chaperone; hsp70 hsp90; sti1; chaperone ... See more keywords
Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug targets"
DOI: 10.2174/1389450117666160527125522
Abstract: BACKGROUND & OBJECTIVE The Hsp90 chaperone protein regulates the folding, maturation and stability of a wide variety of oncoproteins. In recent years, many Hsp90 inhibitors have entered into the clinical trials while all of them… read more here.
Keywords: hsp90 chaperone; hsp90; targeting hsp90; hsp90 cdc37 ... See more keywords
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2017.00724
Abstract: The ATP-dependent 90 kDa heat shock protein, Hsp90, is a major regulator of protein triage, from assisting in nascent protein folding to refolding or degrading aberrant proteins. Tau, a microtubule associated protein, aberrantly accumulates in… read more here.
Keywords: hsp90 chaperone; chaperone machinery; protein; tau ... See more keywords