Hsp90 dependence of a kinase is determined by its conformational landscape
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43996
Abstract: Heat shock protein 90 (Hsp90) is an abundant molecular chaperone, involved in the folding and activation of 60% of the human kinome. The oncogenic tyrosine kinase v-Src is one of the most stringent client proteins… read more here.
Keywords: hsp90 dependence; kinase; conformational landscape;