Heat shock protein 90 inhibitor ameliorates pancreatic fibrosis by degradation of transforming growth factor-β receptor.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110001
Abstract: BACKGROUND AND AIM Pancreatic fibrosis increases pancreatic cancer risk in chronic pancreatitis (CP). Pancreatic stellate cells (PSCs) play a critical role in the pathological processes of pancreatic fibrosis by transforming growth factor β (TGFβ) signal… read more here.
Keywords: hsp90 inhibitor; inhibitor 17aag; inhibitor; pancreatic fibrosis ... See more keywords
Identification of the circRNA-miRNA-mRNA regulatory network of Hsp90 inhibitor-induced cell death in colorectal cancer by integrated analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144232
Abstract: Colorectal cancer (CRC) is a global disease with high incidence and mortality rate. Hsp90 inhibitors induce cell death in various cancers, including CRC. However, the underlying mechanisms need to be clarified further. In this study,… read more here.
Keywords: hsp90; regulatory network; colorectal cancer; cell death ... See more keywords
Molecular detection of Hsp90 inhibitor suppressing PCV2 replication in host cells.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.04.037
Abstract: Porcine Circovirus Type 2 (PCV2) is a pathogen that has the ability to cause devastating disease manifestations in pig populations with major economic implications. Our previous research found that Hsp90 is required for PCV2 production… read more here.
Keywords: hsp90; pcv2; host cells; pcv2 replication ... See more keywords
Comprehensive analysis of lncRNA-mRNA regulatory network in BmNPV infected cells treated with Hsp90 inhibitor.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.09.014
Abstract: Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while… read more here.
Keywords: network; cells treated; analysis; hsp90 inhibitor ... See more keywords
NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s130236
Abstract: Purpose Malignant pheochromocytoma (PCC) is a rare tumor with a very poor prognosis and no effective treatments. The aim of this study was to assess the efficacy of a novel second-generation synthetic heat-shock protein 90… read more here.
Keywords: malignant pheochromocytoma; vitro vivo; vivo; hsp90 inhibitor ... See more keywords
HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.796974
Abstract: Overactivated inflammation and catabolism induced by proinflammatory macrophages are involved in the pathological processes of intervertebral disc (IVD) degeneration (IVDD). Our previous study suggested the protective role of inhibiting heat shock protein 90 (HSP90) in… read more here.
Keywords: aag; catabolism induced; inflammation catabolism; hsp90 inhibitor ... See more keywords
Effects of Hsp90 Inhibitor Ganetespib on Inhibition of Azole-Resistant Candida albicans
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.680382
Abstract: Candida albicans is the most common fungal pathogen. Recently, drug resistance of C. albicans is increasingly severe. Hsp90 is a promising antifungal target to overcome this problem. To evaluate the effects of Hsp90 inhibitor ganetespib… read more here.
Keywords: effects hsp90; candida albicans; azole resistant; hsp90 inhibitor ... See more keywords
Non-steroidal anti-inflammatory drugs sensitize CD44-overexpressing cancer cells to Hsp90 inhibitor through autophagy activation.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology research"
DOI: 10.3727/096504019x15517850319579
Abstract: Recently, novel therapeutic strategies have been designed with the aim of killing cancer stem-like cells (CSCs), and considerable interest has been generated in the development of specific therapies that target stemness-related marker of CSCs. In… read more here.
Keywords: hsp90 inhibitor; cd44highk562 cells; cd44 overexpressing;