Hsp90 mutants with distinct defects provide novel insights into cochaperone regulation of the folding cycle.
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DOI: 10.1371/journal.pgen.1010772
Abstract: Molecular chaperones play a key role in maintaining proteostasis and cellular health. The abundant, essential, cytosolic Hsp90 (Heat shock protein, 90 kDa) facilitates the folding and activation of hundreds of newly synthesized or misfolded client… read more here.
Keywords: cycle; closed conformation; hsp90; hsp90 mutants ... See more keywords