Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2019.1596903
Abstract: Abstract Overexpression of heat shock protein 90 (Hsp90) is common in various types of cancer. In cutaneous melanoma, a cancer with one of the high levels of Hsp90 overexpression, such expression was correlated with a… read more here.
Keywords: protein; melanoma; hsp90 pi3k; kinase ... See more keywords
Abstract 2684: Synergistic efficacy of HSP90 and PI3K inhibitors in adrenocortical carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2684
Abstract: Adrenocortical cancer (ACC) is a rare and aggressive cancer (0.5-2 cases/million/year) with poor 5-year survival. Most patients inevitably succumb to widespread metastasis due to a lack of effective systemic treatment; therefore, it is critically important… read more here.
Keywords: combination; efficacy; pi3k inhibitors; hsp90 pi3k ... See more keywords
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways
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DOI: 10.3390/ijms21051845
Abstract: Melanoma is the deadliest form of skin cancer, and its incidence has continuously increased over the past 20 years. Therefore, the discovery of a novel targeted therapeutic strategy for melanoma is urgently needed. In our… read more here.
Keywords: cell proliferation; pi3k dual; dual inhibitor; hsp90 pi3k ... See more keywords