Structure-Activity Relationship Study of Tertiary Alcohol Hsp90α-Selective Inhibitors with Novel Binding Mode.
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DOI: 10.1021/acsmedchemlett.2c00327
Abstract: The heat shock protein 90 (Hsp90) family of molecular chaperones mediates the folding and activation of client proteins associated with all 10 hallmarks of cancer. Herein, the design, synthesis, and biological validation of Hsp90α-selective inhibitors… read more here.
Keywords: hsp90; novel binding; selective inhibitors; tertiary alcohol ... See more keywords