HSPA12A impairs lipophagy to exaggerate septic cardiomyopathy by promoting MTOR's competition against LC3-II in binding with PNPLA2.
Sign Up to like & getrecommendations! Published in 2025 at "Autophagy"
DOI: 10.1080/15548627.2025.2600895
Abstract: Accumulation of lipid droplets (LDs) in cardiomyocytes contributes to developmentof septic cardiomyopathy, a fatal complication of critical illness in patients.Lipophagy is a selective autophagic mechanism for LD degradation. This processis inhibited by MTOR, but is… read more here.
Keywords: hspa12a; lc3; mtor; septic cardiomyopathy ... See more keywords
HSPA12A Stimulates p38/ERK-AP-1 Signaling to Promote Angiogenesis and Is Required for Functional Recovery Postmyocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2333848
Abstract: Angiogenesis plays a critical role in wound healing postmyocardial infarction (MI). However, there is still a lack of ideal angiogenic therapeutics for rescuing ischemic hearts clinically, suggesting that a more understanding regarding angiogenesis regulation is… read more here.
Keywords: postmyocardial infarction; endothelial cells; p38 erk; hspa12a ... See more keywords