Endothelial cell HSPA12B and yes-associated protein cooperatively regulate angiogenesis following myocardial infarction
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DOI: 10.1172/jci.insight.139640
Abstract: Angiogenesis is essential for cardiac functional recovery after myocardial infarction (MI). HSPA12B is predominately expressed in endothelial cells and required for angiogenesis. Yes-associated protein (YAP) plays an important role in tumor angiogenesis. This study investigated… read more here.
Keywords: angiogenesis; myocardial infarction; endothelial cell; yap ... See more keywords
Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00566
Abstract: Heat shock protein A12B (HSPA12B) is predominately expressed in endothelial cells (ECs) and has been reported to protect against cardiac dysfunction from endotoxemia or myocardial infarction. This study investigated the mechanisms by which endothelial HSPA12B… read more here.
Keywords: sepsis; endothelial hspa12b; mir 126; mice ... See more keywords
Endothelial HSPA12B regulates myocardial monocyte infiltration and inflammatory activity after myocardial infarction
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1587898
Abstract: Introduction Cardiac macrophages are essential mediators of inflammation and tissue remodeling following myocardial infarction (MI). Endothelial cell-specific heat shock protein A12B (eHSPA12B) has emerged as a key vascular regulator, but its role in modulating immune… read more here.
Keywords: hspa12b; monocyte infiltration; myocardial infarction; infiltration ... See more keywords