Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112708
Abstract: The resistance to tyrosine kinase inhibitors is currently a major problem for chronic myeloid leukemia (CML) treatment and HSPA8 is highly expressed and a hallmark of poor prognosis in several human cancers. However, its role… read more here.
Keywords: cml; cml cells; proliferation; bcr abl ... See more keywords
Blocking nuclear export of HSPA8 after heat shock stress severely alters cell survival
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DOI: 10.1038/s41598-018-34887-6
Abstract: The nuclear translocation of endogenous heat shock cognate protein HSPA8 is a requisite for cell survival during oxidative and heat shock stress. Upon these events, cytoplasmic HSPA8 is thought to concentrate within the nucleus and… read more here.
Keywords: cell survival; heat shock; stress; heat ... See more keywords
Heat Shock Protein Member 8 (HSPA8) Is Involved in Porcine Reproductive and Respiratory Syndrome Virus Attachment and Internalization
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DOI: 10.1128/spectrum.01860-21
Abstract: PRRSV has caused huge economic losses to the pork industry around the world. Currently, safe and effective strategies are still urgently required to prevent and control PRRSV infection. ABSTRACT Porcine reproductive and respiratory syndrome virus… read more here.
Keywords: attachment internalization; prrsv infection; hspa8; prrsv ... See more keywords
HSPA8 Is a New Biomarker of Triple Negative Breast Cancer Related to Prognosis and Immune Infiltration
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/8446857
Abstract: Objective Triple negative breast cancer (TNBC) is a kind of cancer that endangers the lives of women all over the world in the 21st century. Heat shock protein member 8 (HSPA8) is the chaperone gene… read more here.
Keywords: breast cancer; hspa8; tnbc; expression ... See more keywords