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   Articles with "hspb1" as a keyword



HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

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recommendations! Published in 2019 at "Science Advances"

DOI: 10.1126/sciadv.aav8421

Abstract: The molecular chaperone HspB1 regulates the biomechanical extension of the heart muscle protein filamin C upon stress. Mechanical force–induced conformational changes in proteins underpin a variety of physiological functions, typified in muscle contractile machinery. Mutations… read more here.

Keywords: chaperone; filamin; hspb1 phosphorylation; interaction ... See more keywords

Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection

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recommendations! Published in 2024 at "Science Advances"

DOI: 10.1126/sciadv.adk9884

Abstract: Molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques and intracellular tau neurofibrillary tangles in Alzheimer’s disease (AD). In addition, AD is characterized by an increase… read more here.

Keywords: hspb1; secrete chaperone; astrocytes secrete; reactive astrocytes ... See more keywords

HSPB1 Gene Variants and Schizophrenia: A Case-Control Study in a Polish Population

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recommendations! Published in 2022 at "Disease Markers"

DOI: 10.1155/2022/4933011

Abstract: Schizophrenia (SCZ) is a severe psychiatric disorder that has a significant genetic component. HSPB1 (HSP27) is known for its neuroprotective functions under stress conditions and appears to play an important role during the development of… read more here.

Keywords: hspb1; case control; polish population; control study ... See more keywords

Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

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recommendations! Published in 2017 at "Acta Neuropathologica Communications"

DOI: 10.1186/s40478-016-0407-3

Abstract: The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So far disease causing mutations in HSPB1 have… read more here.

Keywords: rna; rna binding; disease; translational repression ... See more keywords

HSPB1 alleviates acute-on-chronic liver failure via the P53/Bax pathway

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recommendations! Published in 2024 at "Open Life Sciences"

DOI: 10.1515/biol-2022-0919

Abstract: Abstract The mortality rate of acute-on-chronic liver failure (ACLF) remains significantly elevated; hence, this study aimed to investigate the impact of heat shock protein family B (small) member 1 (HSPB1) on ACLF in vivo and… read more here.

Keywords: hspb1; chronic liver; p53; liver failure ... See more keywords

Heterogeneous Clinical Phenotypes of dHMN Caused by Mutation in HSPB1 Gene: A Case Series

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12101382

Abstract: Mutations in HSPB1 are known to cause Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). In this study, we presented three patients with mutation in HSPB1 who were diagnosed with dHMN. Proband… read more here.

Keywords: proband year; mutation hspb1; hspb1; year old ... See more keywords

Tat-hspb1 Suppresses Clear Cell Renal Cell Carcinoma (ccRCC) Growth via Lysosomal Membrane Permeabilization

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers14225710

Abstract: Simple Summary In this study, we discovered a novel endogenous peptide derived from HSPB1 protein through peptidomic analysis of human renal clear cell carcinoma and adjacent normal tissues. We generated a new peptide by conjugating… read more here.

Keywords: cell carcinoma; hspb1; ccrcc; tat hspb1 ... See more keywords

The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23137317

Abstract: Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a… read more here.

Keywords: hspb1; small heat; heat shock; membrane ... See more keywords

Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1

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recommendations! Published in 2024 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.84494

Abstract: Acute pancreatitis (AP) is a common abdominal disease that typically resolves on its own, but the mortality rate dramatically increases when it progresses to severe acute pancreatitis (SAP). In this study, we investigated the molecular… read more here.

Keywords: mice; prdx1; hspb1; pancreatitis ... See more keywords