Effect of cataract-associated mutations in the N-terminal domain of αB-crystallin (HspB5).
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108091
Abstract: Physico-chemical properties of three cataract-associated missense mutants of αB-crystallin (HspB5) (R11H, P20S, R56W) were analyzed. The oligomers formed by the R11H mutant were smaller, whereas the oligomers of the P20S and R56W mutants were larger… read more here.
Keywords: crystallin hspb5; cataract associated; hspb5; crystallin ... See more keywords
Effects of Molecular Crowding and Betaine on HSPB5 Interactions, with Target Proteins Differing in the Quaternary Structure and Aggregation Mechanism
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DOI: 10.3390/ijms232315392
Abstract: The aggregation of intracellular proteins may be enhanced under stress. The expression of heat-shock proteins (HSPs) and the accumulation of osmolytes are among the cellular protective mechanisms in these conditions. In addition, one should remember… read more here.
Keywords: aggregation; betaine; hspb5; activity ... See more keywords
HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling
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DOI: 10.3390/ph16020177
Abstract: Idiopathic pulmonary fibrosis is a chronic, progressive and lethal disease of unknown etiology that ranks among the most frequent interstitial lung diseases. Idiopathic pulmonary fibrosis is characterized by dysregulated healing mechanisms that lead to the… read more here.
Keywords: hspb5; nci 41356; lung; fibrosis ... See more keywords