DUSP12 ameliorates myocardial ischemia–reperfusion injury through HSPB8‐induced mitophagy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23310
Abstract: This study aimed to explore the role of dual specificity phosphatase 12 (DUSP12) in regulating myocardial ischemia–reperfusion (I/R) injury and the underlying mechanism. The expression of DUSP12 in myocardial tissues and heat‐shock protein beta‐8 (HSPB8)… read more here.
Keywords: hspb8; h9c2 cells; myocardial ischemia; myocardial tissues ... See more keywords
Silica Nanoparticles Trigger Chaperone HSPB8-Assisted Selective Autophagy via TFEB Activation in Hepatocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204310
Abstract: Silica nanoparticles (SiNPs) are one of the most common inorganic nanomaterials. Autophagy is the predominant biological response to nanoparticles and transcription factor EB (TFEB) is a master regulator of the autophagy-lysosome pathway. Previous studies show… read more here.
Keywords: tfeb; assisted selective; silica nanoparticles; hspb8 ... See more keywords
HSPB8 Overexpression Ameliorates Cognitive Impairment in Diabetic Mice via Inhibiting NLRP3 Inflammation Activation
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9251835
Abstract: Type 2 diabetes mellitus (T2DM) is associated with an elevated risk of cognitive impairment. And the underlying mechanism remains unillustrated. HSPB8 is a member of the small heat shock protein family. In this study, we… read more here.
Keywords: hspb8; diabetic mice; hspb8 overexpression; cognitive impairment ... See more keywords
New family with HSPB8-associated autosomal dominant rimmed vacuolar myopathy
Sign Up to like & getrecommendations! Published in 2019 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000000349
Abstract: Objective We clinically and molecularly characterize a new family with autosomal dominant rimmed vacuolar myopathy (RVM) caused by mutations in the HSPB8 gene. Methods We performed whole-exome and whole-genome sequencing in the family. Western blot… read more here.
Keywords: hspb8; pathology; dominant rimmed; autosomal dominant ... See more keywords
HSPB8 is a Potential Prognostic Biomarker that Correlates With Immune Cell Infiltration in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.804858
Abstract: Background: Heat shock protein B8 (HSPB8) is expressed in various cancers. However, the functional and clinicopathological significance of HSPB8 expression in bladder cancer (BC) remains unclear. The present study sought to elucidate the clinicopathological features… read more here.
Keywords: infiltration; bladder; cell infiltration; immune cell ... See more keywords
HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.69377
Abstract: Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic. Here, we develop quantitative time-resolved crosslinking mass spectrometry to monitor protein… read more here.
Keywords: hspb8; phase transitions; folded rna; domain ... See more keywords