Cebpa is required for haematopoietic stem and progenitor cell generation and maintenance in zebrafish
Sign Up to like & getrecommendations! Published in 2024 at "Open Biology"
DOI: 10.1098/rsob.240215
Abstract: The CCAAT enhancer binding protein alpha (CEBPA) is crucial for myeloid differentiation and the balance of haematopoietic stem and progenitor cell (HSPC) quiescence and self-renewal, and its dysfunction can drive leukemogenesis. However, its role in… read more here.
Keywords: haematopoietic stem; generation; cebpa; hspc ... See more keywords
Abstract 1194: Adoptive cellular therapy overcomes tumor-induced dysregulation of myelopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1194
Abstract: INTRODUCTION: Hematopoietic stem and progenitor cell (HSPC) transfer during adoptive T cell immunotherapy (ACT) prolongs median survival and generates 30% long-term cures for malignant brain tumors. We recently demonstrated during ACT that intratumoral HSPCs differentiate… read more here.
Keywords: adoptive cellular; naive hspcs; cell; hspc ... See more keywords
miR-499 in Platelet-Derived Extracellular Vesicles Augments Inflammatory Cell Generation and Cardiac Remodeling After Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circulationaha.124.073527
Abstract: BACKGROUND Emergency myelopoiesis by bone marrow hematopoietic stem and progenitor cells (HSPCs) exacerbates disease pathology in various chronic diseases, including myocardial infarction (MI) and atherosclerosis. However, the mechanisms triggering myelopoiesis in the bone marrow after… read more here.
Keywords: inflammatory cell; mir 499; cell generation; hspc ... See more keywords
Ezh1 Inhibits Commitment to Hemogenic Fate and HSPC Formation during Vertebrate Development
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131464
Abstract: Understanding how hematopoietic stem cells (HSCs) are specified from mesodermal precursors is essential to the goal of generating patient-specific HSCs capable of multi-potent long-term function. HSCs are born from hemogenic endothelium in select arterial niches… read more here.
Keywords: ezh1; notch; hspc; commitment ... See more keywords
Liposomal melatonin targets mutant hematopoiesis and bone marrow remodeling in MPN
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-1493
Abstract: IntroductionMyeloproliferative neoplasms (MPN) are chronic hematological disorders characterized by clonal expansion of the myeloid lineage, inflammation, and oxidative stress that may lead to bone marrow (BM) fibrosis. Allogeneic stem cell transplantation remains the only curative… read more here.
Keywords: bone marrow; nano; hspc; blood ... See more keywords
Profiling of exceptional responders (ER) and non-responders (NR) to androgen receptor pathway inhibitors (ARPI) in men with metastatic hormone sensitive and castration resistant prostate cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e17107
Abstract: e17107 Background: In clinical practicea subset of patients treated with androgen deprivation therapy (ADT) plus an ARPI achieve prolonged benefit (ER) while some patients experience early resistance (NR), in both metastatic hormone-sensitive (HSPC) and castrate-resistant… read more here.
Keywords: lack tp53; metastatic hormone; hormone sensitive; lack ... See more keywords
Design and development of pH-responsive HSPC:C12H25-PAA chimeric liposomes
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DOI: 10.3109/08982104.2016.1166512
Abstract: Abstract The application of stimuli-responsive medical practices has emerged, in which pH-sensitive liposomes figure prominently. This study investigates the impact of the incorporation of different amounts of pH-sensitive polymer, C12H25-PAA (poly(acrylic acid) with a hydrophobic… read more here.
Keywords: c12h25 paa; hspc; development responsive; design development ... See more keywords
Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.280329
Abstract: Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemoresistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hema-topoietic stem/progenitor cells… read more here.
Keywords: pseudo mutant; hspc; p53; prel hspc ... See more keywords
Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18020199
Abstract: An understanding of the cell interactions occurring in the leukemic microenvironment and their functional consequences for the different cell players has therapeutic relevance. By co-culturing mesenchymal stem cells (MSC) with the REH acute lymphocytic leukemia… read more here.
Keywords: leukemic niche; hspc; hematopoietic stem; stem ... See more keywords