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   Articles with "hspc" as a keyword



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Abstract 1194: Adoptive cellular therapy overcomes tumor-induced dysregulation of myelopoiesis

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recommendations! Published in 2019 at "Tumor Biology"

DOI: 10.1158/1538-7445.am2019-1194

Abstract: INTRODUCTION: Hematopoietic stem and progenitor cell (HSPC) transfer during adoptive T cell immunotherapy (ACT) prolongs median survival and generates 30% long-term cures for malignant brain tumors. We recently demonstrated during ACT that intratumoral HSPCs differentiate… read more here.

Keywords: adoptive cellular; naive hspcs; cell; hspc ... See more keywords
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Ezh1 Inhibits Commitment to Hemogenic Fate and HSPC Formation during Vertebrate Development

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-131464

Abstract: Understanding how hematopoietic stem cells (HSCs) are specified from mesodermal precursors is essential to the goal of generating patient-specific HSCs capable of multi-potent long-term function. HSCs are born from hemogenic endothelium in select arterial niches… read more here.

Keywords: ezh1; notch; hspc; commitment ... See more keywords
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Design and development of pH-responsive HSPC:C12H25-PAA chimeric liposomes

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recommendations! Published in 2017 at "Journal of Liposome Research"

DOI: 10.3109/08982104.2016.1166512

Abstract: Abstract The application of stimuli-responsive medical practices has emerged, in which pH-sensitive liposomes figure prominently. This study investigates the impact of the incorporation of different amounts of pH-sensitive polymer, C12H25-PAA (poly(acrylic acid) with a hydrophobic… read more here.

Keywords: c12h25 paa; hspc; development responsive; design development ... See more keywords
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Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia

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recommendations! Published in 2022 at "Haematologica"

DOI: 10.3324/haematol.2021.280329

Abstract: Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemoresistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hema-topoietic stem/progenitor cells… read more here.

Keywords: pseudo mutant; hspc; p53; prel hspc ... See more keywords
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Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment

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recommendations! Published in 2017 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms18020199

Abstract: An understanding of the cell interactions occurring in the leukemic microenvironment and their functional consequences for the different cell players has therapeutic relevance. By co-culturing mesenchymal stem cells (MSC) with the REH acute lymphocytic leukemia… read more here.

Keywords: leukemic niche; hspc; hematopoietic stem; stem ... See more keywords