The gp130 Cytokine Interleukin‐11 Regulates Engraftment of Vav1–/– Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2760
Abstract: During bone marrow transplantation, hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1,… read more here.
Keywords: irradiated recipients; stem progenitor; hematopoietic stem; hspcs ... See more keywords
Fenofibrate increases circulating haematopoietic stem cells in people with diabetic retinopathy: a randomised, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05532-1
Abstract: In two large RCTs, fenofibrate reduced the progression of diabetic retinopathy. We investigated whether fenofibrate increases circulating haematopoietic stem/progenitor cells (HSPCs), which have vascular properties and have been shown to protect from retinopathy. We conducted… read more here.
Keywords: hspcs; diabetic retinopathy; placebo; group ... See more keywords
Disease modeling of bone marrow failure syndromes using iPSC-derived hematopoietic stem progenitor cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.01.006
Abstract: The plasticity of induced pluripotent stem cells (iPSCs) with the potential to differentiate into virtually any type of cells and the feasibility of generating hematopoietic stem progenitor cells (HSPCs) from patient-derived iPSCs (iPSC-HSPCs) has many… read more here.
Keywords: progenitor cells; hematology; stem progenitor; hematopoietic stem ... See more keywords
2008 – ADULT HEMATOPOIETIC STEM CELL CLONALITY IS DETERMINED BY EMBRYONIC MACROPHAGE SENSING OF CALRETICULIN
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DOI: 10.1016/j.exphem.2020.09.170
Abstract: In development local signals induce hematopoietic stem cell (HSC) emergence, trafficking, and division. Using a brainbow color barcoding system, we previously found that zebrafish produce 20-30 HSCs in the embryonic aorta. Using spinning disk confocal… read more here.
Keywords: stem cell; embryonic macrophage; cell; hspcs ... See more keywords
2009 – THE NEUROTRANSMITTER RECEPTOR GABBR1 REGULATES PROLIFERATION AND FUNCTION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.171
Abstract: Hematopoietic stem and progenitor cells (HSPCs) have multi-lineage potential and can be used in transplants as a curative treatment for various hematopoietic diseases. HSPC function and behavior is tightly regulated by various cell types and… read more here.
Keywords: gabbr1; cell; hspcs; hematopoietic stem ... See more keywords
Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains
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DOI: 10.1016/j.stemcr.2018.06.011
Abstract: Summary C57BL/6N (N) and C57BL/6J (J) mice possess key genetic differences, including a deletion in the Nicotinamide nucleotide transhydrogenase (Nnt) gene that results in a non-functional protein in J mice. NNT regulates mitochondrial oxidative stress.… read more here.
Keywords: function; c57bl; stress; hspcs ... See more keywords
Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria.
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DOI: 10.1053/j.seminhematol.2022.08.004
Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder caused by a mutation of the X-linked PIGA gene, resulting in a deficient expression of glycosylphosphatidylinositol (GPI)-anchored proteins. While large clonal expansions of… read more here.
Keywords: gpi; gpi hspcs; nocturnal hemoglobinuria; paroxysmal nocturnal ... See more keywords
Microbial Sensing by Hematopoietic Stem and Progenitor Cells.
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DOI: 10.1093/stmcls/sxab007
Abstract: Balanced production of immune cells is critical for the maintenance of steady-state immune surveillance, and increased production of myeloid cells is sometimes necessary to eliminate pathogens. Hematopoietic stem and progenitor cell (HSPC) sensing of commensal… read more here.
Keywords: microbial sensing; stem progenitor; hematopoietic stem; hspcs ... See more keywords
Impaired Hematopoietic Stem/Progenitor Cell Traffic and Multi-organ Damage in Diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac035
Abstract: Abstract During antenatal development, hematopoietic stem/progenitor cells (HSPCs) arise from a specialized endothelium and migrate from the extraembryonic mesoderm to the fetal liver before establishing hematopoiesis in the bone marrow (BM). It is still debated… read more here.
Keywords: damage; stem progenitor; traffic; hematopoietic stem ... See more keywords
Abstract 1194: Adoptive cellular therapy overcomes tumor-induced dysregulation of myelopoiesis
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-1194
Abstract: INTRODUCTION: Hematopoietic stem and progenitor cell (HSPC) transfer during adoptive T cell immunotherapy (ACT) prolongs median survival and generates 30% long-term cures for malignant brain tumors. We recently demonstrated during ACT that intratumoral HSPCs differentiate… read more here.
Keywords: adoptive cellular; naive hspcs; cell; hspc ... See more keywords
Highly Efficient Editing of the Beta-Globin Gene in Patient Derived Hematopoietic Stem and Progenitor Cells to Treat Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-117371
Abstract: Sickle cell disease (SCD) is an inherited blood disorder associated with a debilitating chronic illness. SCD is caused by a point mutation in the β-globin gene (HBB). A single nucleotide substitution converts glutamic acid to… read more here.
Keywords: scd hspcs; globin gene; target; gene edited ... See more keywords