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   Articles with "hspcs" as a keyword



The gp130 Cytokine Interleukin‐11 Regulates Engraftment of Vav1–/– Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients

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recommendations! Published in 2018 at "STEM CELLS"

DOI: 10.1002/stem.2760

Abstract: During bone marrow transplantation, hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1,… read more here.

Keywords: irradiated recipients; stem progenitor; hematopoietic stem; hspcs ... See more keywords

Fenofibrate increases circulating haematopoietic stem cells in people with diabetic retinopathy: a randomised, placebo-controlled trial

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recommendations! Published in 2021 at "Diabetologia"

DOI: 10.1007/s00125-021-05532-1

Abstract: In two large RCTs, fenofibrate reduced the progression of diabetic retinopathy. We investigated whether fenofibrate increases circulating haematopoietic stem/progenitor cells (HSPCs), which have vascular properties and have been shown to protect from retinopathy. We conducted… read more here.

Keywords: hspcs; diabetic retinopathy; placebo; group ... See more keywords

Disease modeling of bone marrow failure syndromes using iPSC-derived hematopoietic stem progenitor cells.

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recommendations! Published in 2019 at "Experimental hematology"

DOI: 10.1016/j.exphem.2019.01.006

Abstract: The plasticity of induced pluripotent stem cells (iPSCs) with the potential to differentiate into virtually any type of cells and the feasibility of generating hematopoietic stem progenitor cells (HSPCs) from patient-derived iPSCs (iPSC-HSPCs) has many… read more here.

Keywords: progenitor cells; hematology; stem progenitor; hematopoietic stem ... See more keywords

2008 – ADULT HEMATOPOIETIC STEM CELL CLONALITY IS DETERMINED BY EMBRYONIC MACROPHAGE SENSING OF CALRETICULIN

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recommendations! Published in 2020 at "Experimental Hematology"

DOI: 10.1016/j.exphem.2020.09.170

Abstract: In development local signals induce hematopoietic stem cell (HSC) emergence, trafficking, and division. Using a brainbow color barcoding system, we previously found that zebrafish produce 20-30 HSCs in the embryonic aorta. Using spinning disk confocal… read more here.

Keywords: stem cell; embryonic macrophage; cell; hspcs ... See more keywords

2009 – THE NEUROTRANSMITTER RECEPTOR GABBR1 REGULATES PROLIFERATION AND FUNCTION OF HEMATOPOIETIC STEM AND PROGENITOR CELLS

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recommendations! Published in 2020 at "Experimental Hematology"

DOI: 10.1016/j.exphem.2020.09.171

Abstract: Hematopoietic stem and progenitor cells (HSPCs) have multi-lineage potential and can be used in transplants as a curative treatment for various hematopoietic diseases. HSPC function and behavior is tightly regulated by various cell types and… read more here.

Keywords: gabbr1; cell; hspcs; hematopoietic stem ... See more keywords

Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains

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recommendations! Published in 2018 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2018.06.011

Abstract: Summary C57BL/6N (N) and C57BL/6J (J) mice possess key genetic differences, including a deletion in the Nicotinamide nucleotide transhydrogenase (Nnt) gene that results in a non-functional protein in J mice. NNT regulates mitochondrial oxidative stress.… read more here.

Keywords: function; c57bl; stress; hspcs ... See more keywords

Loss of hematopoietic progenitors heterogeneity is an adverse prognostic factor in lower-risk myelodysplastic neoplasms

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recommendations! Published in 2024 at "Leukemia"

DOI: 10.1038/s41375-024-02234-6

Abstract: Myelodysplastic neoplasms (MDS) are characterized by clonal evolution starting from the compartment of hematopoietic stem and progenitors cells (HSPCs), leading in some cases to leukemic transformation. We hypothesized that deciphering the diversity of the HSPCs… read more here.

Keywords: hspcs; risk; lower risk; mds ... See more keywords

Overexpression of miR-99a promoted expansion and suppressed differentiation of hematopoietic stem/progenitor cells

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-92827-7

Abstract: MicroRNAs (miRNAs) are a class of non-coding RNAs involved in a variety of pathophysiological processes. We have previously reported that the abnormally high expression of miR-99a is associated with drug resistance and poor prognosis in… read more here.

Keywords: differentiation; hematopoietic stem; hspcs; mir 99a ... See more keywords

Somatic mutations and clonal expansions in paroxysmal nocturnal hemoglobinuria.

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recommendations! Published in 2022 at "Seminars in hematology"

DOI: 10.1053/j.seminhematol.2022.08.004

Abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder caused by a mutation of the X-linked PIGA gene, resulting in a deficient expression of glycosylphosphatidylinositol (GPI)-anchored proteins. While large clonal expansions of… read more here.

Keywords: gpi; gpi hspcs; nocturnal hemoglobinuria; paroxysmal nocturnal ... See more keywords

Functional and molecular analyses reveal impaired HSPCs in Multiple Myeloma patients post-induction

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recommendations! Published in 2025 at "Stem Cells Translational Medicine"

DOI: 10.1093/stcltm/szaf061

Abstract: Abstract High-dose chemotherapy and consecutive autologous stem cell transplantation (ASCT) remain the backbone of treatment for transplant-eligible patients of Multiple Myeloma (MM). However, patients are still at high risk of relapse or treatment-related complications. Hence,… read more here.

Keywords: multiple myeloma; hspcs; stem; high risk ... See more keywords

Microbial Sensing by Hematopoietic Stem and Progenitor Cells.

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recommendations! Published in 2022 at "Stem cells"

DOI: 10.1093/stmcls/sxab007

Abstract: Balanced production of immune cells is critical for the maintenance of steady-state immune surveillance, and increased production of myeloid cells is sometimes necessary to eliminate pathogens. Hematopoietic stem and progenitor cell (HSPC) sensing of commensal… read more here.

Keywords: microbial sensing; stem progenitor; hematopoietic stem; hspcs ... See more keywords