Human Mitochondrial Protein HSPD1 Binds to and Regulates the Repair of Deoxyinosine in DNA.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00854
Abstract: The generation of deoxyinosine (dI) in DNA is one of the most important sources of genetic mutations, which may lead to cancer and other human diseases. A further understanding of the biological consequences of dI… read more here.
Keywords: deoxyinosine dna; dna; hspd1; protein hspd1 ... See more keywords
Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular research"
DOI: 10.1093/cvr/cvaa158
Abstract: BACKGROUND During heart failure, the levels of circulatory HSPD1 (HSP60) increase. However, its underlying mechanism is still unknown. The apical domain of HSPD1 is conserved throughout evolution. We found a point mutation in HSPD1 in… read more here.
Keywords: point mutation; hspd1; dcm; mitochondrial dysfunction ... See more keywords
miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/4708516
Abstract: Redox imbalance plays an important role in the pathogenesis of CKD progression. Previously, we demonstrated that microRNA-382 (miR-382) contributed to TGF-β1-induced loss of epithelial polarity in human kidney epithelial cells, but its role in the… read more here.
Keywords: mir 382; mir; tubulointerstitial fibrosis; hspd1 ... See more keywords