Whole exome sequencing reveals heparan sulfate proteoglycan 2 (HSPG2) as a potential causative gene for kidney stone disease in a Thai family
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DOI: 10.1007/s00240-024-01674-0
Abstract: Kidney stone disease (KSD) is a prevalent and complex condition, with an incidence of 85 cases per 100,000 individuals in Thailand. Notably, over 40% of cases are concentrated in the northeastern region, indicating a potential… read more here.
Keywords: kidney stone; hspg2; family; stone disease ... See more keywords
The Association between Genes Polymorphisms of Heparan Sulfate Proteoglycan 2 (HSPG2) and Chondroitin Sulfate Proteoglycan 2 (CSPG2) and Intracranial Aneurysm Susceptibility: A Meta-Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Iranian Journal of Public Health"
DOI: 10.18502/ijph.v48i11.3512
Abstract: Background: We aimed to investigate whether the polymorphisms of gene heparan sulfate proteoglycan 2 (HSPG2) and chondroitin sulfate proteoglycan 2 (CSPG2) are associated with increased risk of intracranial aneurysms (IAs) susceptibility. Methods: The Cochrane Library,… read more here.
Keywords: cspg2; heparan sulfate; susceptibility; hspg2 ... See more keywords
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
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DOI: 10.3389/fcell.2024.1452463
Abstract: Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling. To define these mechanisms, we employed a DU145 PC model to conduct a… read more here.
Keywords: hspg2; perlecan hspg2; extracellular matrix; prostate cancer ... See more keywords
Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions
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DOI: 10.3390/genes9110556
Abstract: Heparan sulfate proteoglycan 2 (HSPG2) is an essential, highly conserved gene whose expression influences many developmental processes including the formation of the heart and brain. The gene is widely expressed throughout the musculoskeletal system including… read more here.
Keywords: proteoglycan perlecan; perlecan hspg2; hspg2; hspg2 mutations ... See more keywords