Treatment with 2-methoxyestradiol increases endothelial nitric oxide synthase activity via scavenger receptor class BI in human umbilical vein endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaaa028
Abstract: Concentrations of 2-methoxyestradiol (2ME2), a principal metabolite of estradiol, are significantly lower in women with severe preeclampsia. Nitric oxide (NO) released by endothelial nitric oxide synthase (eNOS) plays an important role in regulating cardiovascular homeostasis.… read more here.
Keywords: nitric oxide; treatment; hsr cla; activity ... See more keywords
AGEs inhibit scavenger receptor class B type I gene expression via Smad1 in HUVECs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-20-0177
Abstract: Vascular complications are the main cause of morbidity and mortality in diabetic patients, and advanced glycation end products (AGEs) play a critical role in promoting diabetic vascular dysfunction. The human homolog of scavenger receptor class… read more here.
Keywords: expression; hsr cla; smad1; receptor ... See more keywords