Novel mutations in antiviral multiresistant HSV‐2 genital lesion: A case report
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DOI: 10.1002/jmv.28070
Abstract: HSV‐2 antiviral resistance mainly occurs in immunocompromised patients and especially in HIV‐positive individuals receiving long‐term antiviral treatment. Those situations can be challenging as few alternatives are available for HSV infection management. To describe clinical and… read more here.
Keywords: hsv genital; hsv; genital lesion; resistance ... See more keywords
The association between serum 25‐hydroxyvitamin D and the prevalence of herpes simplex virus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28297
Abstract: Previous studies have reported a potential anti‐infection effect for vitamin D. However, the relationship between vitamin D status and herpes simplex virus (HSV) infection has not yet been evaluated. Therefore, this study aimed to determine… read more here.
Keywords: serum; infection; hsv; hsv hsv ... See more keywords
Langerhans cells and sexual transmission of HIV and HSV
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DOI: 10.1002/rmv.1923
Abstract: Langerhans cells (LCs) situated in stratified squamous epithelium of the skin and mucosal tissue are amongst the first cells that sexually transmitted pathogens encounter during transmission. They are potent antigen presenting cells and play a… read more here.
Keywords: hsv; transmission; hiv; role ... See more keywords
Expression, Purification, and Crystallization of HSV-1 Glycoproteins for Structure Determination.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9814-2_23
Abstract: Herpes simplex viruses utilize glycoproteins displayed on the viral envelope to perform a variety of functions in the viral infectious cycle. Structural and functional studies of these viral glycoproteins can benefit from biochemical, biophysical, and structural analysis of… read more here.
Keywords: purification crystallization; hsv; expression purification;
Use of computed tomography volumetric measurements to predict operative techniques in paraesophageal hernia repair
Sign Up to like & getrecommendations! Published in 2019 at "Surgical Endoscopy"
DOI: 10.1007/s00464-019-06930-8
Abstract: Background Despite advances in diagnostic imaging capabilities, little information exists concerning the impact of physical dimensions of a paraesophageal hernia (PEH) on intraoperative decision making. The authors hypothesized that computerized volumetric analysis and multidimensional visualization… read more here.
Keywords: hsv; hda; volumetric measurements; paraesophageal hernia ... See more keywords
Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation
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DOI: 10.1007/s00726-018-2590-y
Abstract: Bile acid prodrugs have served as a viable strategy for refining the pharmaceutical profile of parent drugs through utilizing bile acid transporters. A series of three ester prodrugs of the antiherpetic drug acyclovir (ACV) with… read more here.
Keywords: acv; hsv; plasma stability; antiviral activity ... See more keywords
Reducing Viral Inhibition of Host Cellular Apoptosis Strengthens the Immunogenicity and Protective Efficacy of an Attenuated HSV-1 Strain
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00156-7
Abstract: Herpes simplex virus 1 (HSV-1), a member of α herpesviruses, shows a high infectivity rate of 30%–60% in populations of various ages. Some herpes simplex (HSV) vaccine candidates evaluated during the past 20 years have… read more here.
Keywords: hsv; cellular apoptosis; hsv strain; protective efficacy ... See more keywords
Pemphigus et surinfection herpétique : audit de pratiques multicentrique
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DOI: 10.1016/j.annder.2017.09.219
Abstract: Introduction La prevalence et les circonstances de survenue des surinfections herpetiques (SH) du pemphigus (P) restent peu connues. Nous avons mene une etude multicentrique retrospective pour en etudier les caracteristiques. Patients et methodes Parmi tous… read more here.
Keywords: hsv; par; ttt; prevalence ... See more keywords
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis
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DOI: 10.1016/j.antiviral.2017.11.002
Abstract: ABSTRACT Pritelivir, a helicase‐primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir‐resistant strains, were treated 72 h… read more here.
Keywords: pritelivir; hsv; treatment; simplex encephalitis ... See more keywords
Viral ribonucleotide reductase attenuates the anti-herpes activity of acyclovir in contrast to amenamevir.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104829
Abstract: Amenamevir is a helicase-primase inhibitor of herpes simplex virus (HSV) and varicella-zoster virus (VZV) and is used for the treatment of herpes zoster in Japan. The half maximal effective concentrations (EC50s) of acyclovir and sorivudine… read more here.
Keywords: amenamevir; hsv; anti herpes; activity ... See more keywords
Helicase primase inhibitors (HPIs) are efficacious for therapy of human herpes simplex virus (HSV) disease in an infection mouse model.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105190
Abstract: Although the seroprevalence of Herpes simplex virus type 1 (HSV-1) currently amounts to ∼ 67% worldwide, the annual incidence of a severe disease progression, particularly herpes encephalitis, is approximately 2-4 cases per 1,000,000 infections. Nucleoside analogues, such… read more here.
Keywords: hsv; treatment; disease; therapy ... See more keywords