Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo
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DOI: 10.1371/journal.ppat.1009848
Abstract: HSV glycoprotein K (gK) is an essential herpes protein that contributes to enhancement of eye disease. We previously reported that gK binds to signal peptide peptidase (SPP) and that depletion of SPP reduces HSV-1 infectivity… read more here.
Keywords: peptide; hsv glycoprotein; virus infectivity; signal peptide ... See more keywords