Microglia innate immune response contributes to the antiviral defense and blood–CSF barrier function in human choroid plexus organoids during HSV‐1 infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28472
Abstract: The choroid plexus (ChP) is the source of cerebrospinal fluid (CSF). The ChP–CSF system not only provides the necessary cushion for the brain but also works as a sink for waste clearance. During sepsis, pathogens… read more here.
Keywords: csf; barrier; hsv infection; innate immune ... See more keywords
HSV‐1 infection‐induced herpetic neuralgia involves a CCL5/CCR5‐mediated inflammation mechanism
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28718
Abstract: Herpetic‐related neuralgia (HN) caused by varicella‐zoster virus (VZV) infection is one of the most typical and common neuropathic pain in the clinic. However, the potential mechanisms and therapeutic approaches for the prevention and treatment of… read more here.
Keywords: infection induced; infection; hsv infection; spinal cord ... See more keywords
Pathological processes activated by herpes simplex virus-1 (HSV-1) infection in the cornea
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2938-1
Abstract: Herpes simplex virus type-1 (HSV-1) is a ubiquitous pathogen that infects a large majority of the human population worldwide. It is also a leading cause of infection-related blindness in the developed world. HSV-1 infection of… read more here.
Keywords: infection; infection cornea; hsv infection; herpes simplex ... See more keywords
Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2019.104598
Abstract: Abstract As antiviral drug resistance develops and new viruses emerge there is a pressing need to develop strategies to rapidly develop antiviral therapeutics. Here we use phospho-specific flow cytometry to assess perturbations of many different… read more here.
Keywords: ribavirin; antiviral drug; cellular signaling; drug ... See more keywords
Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105116
Abstract: Growing evidence supports that chronic or latent infection of the central nervous system might be implicated in Alzheimer's disease (AD). Among them, Herpes simplex virus type 1 (HSV-1) has emerged as a major factor in… read more here.
Keywords: regulates hsv; matrix metalloproteinase; metalloproteinase regulates; infection ... See more keywords
PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV‐1 infection
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DOI: 10.1016/j.exer.2017.06.015
Abstract: ABSTRACT Herpes simplex virus type‐1 (HSV‐1) infection leads to impaired corneal sensation and, in severe cases, to corneal ulceration, melting and perforation. Here, we explore the potential therapeutic action of pigment epithelial‐derived factor (PEDF) plus… read more here.
Keywords: hsv infection; treatment; dha; pedf ... See more keywords
The association between herpes simplex virus type 1 infection and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.10.044
Abstract: There is growing evidence demonstrating the relationship between herpes simplex virus type 1 (HSV-1) infection and Alzheimer's disease (AD). We searched PubMed, Embase, and Cochrane databases for relevant articles. The Newcastle-Ottawa Scale (NOS) was used… read more here.
Keywords: virus type; infection; hsv infection; infection alzheimer ... See more keywords
Herpes simplex virus and Alzheimer's disease: a Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.09.025
Abstract: This study assessed if any herpes simplex virus (HSV) infection was a genetically valid target for late-onset Alzheimer's disease (AD) using 2-sample Mendelian randomization. We applied strong (p-value read more here.
Keywords: late onset; alzheimer disease; infection; hsv infection ... See more keywords
Effect of castalagin against HSV-1 infection in newborn mice.
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DOI: 10.1080/14786419.2023.2173191
Abstract: We tested in vivo anti-herpetic effect of castalagin, an ellagitannin compound, extracted from pedunculate oak (Quercus robur). Previous investigations found that castalagin possesses a strong inhibitory effect in vitro against HSV-1/2 equal to acyclovir (ACV). It is… read more here.
Keywords: effect; castalagin; hsv infection; effect castalagin ... See more keywords
Aβ plaques do not protect against HSV‐1 infection in a mouse model of familial Alzheimer's disease, and HSV‐1 does not induce Aβ pathology in a model of late onset Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13116
Abstract: The possibility that the etiology of late onset Alzheimer's disease is linked to viral infections of the CNS has been actively debated in recent years. According to the antiviral protection hypothesis, viral pathogens trigger aggregation… read more here.
Keywords: alzheimer disease; infection; hsv infection; pathology ... See more keywords
HSV-1 Infection Induces a Downstream Shift of Promoter-Proximal Pausing for Host Genes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00381-23
Abstract: This study provides a genome-wide analysis of changes in promoter-proximal polymerase II (Pol II) pausing on host genes induced by HSV-1 infection. It shows that standard measures of pausing, i.e., pausing indices, do not properly… read more here.
Keywords: infection; hsv infection; promoter proximal; pol pausing ... See more keywords