Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01311-21
Abstract: One of the most devastating and acute neurological conditions is encephalitis, i.e., inflammation of brain tissue. Herpes simplex virus 1 (HSV1) is a highly prevalent pathogen in humans, and the most frequent cause of viral… read more here.
Keywords: hsv1; microglia depletion; brain; encephalitis ... See more keywords
Adaptation of transgene mRNA translation boosts the anticancer efficacy of oncolytic HSV1
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006408
Abstract: Background Transgenes deliver therapeutic payloads to improve oncolytic virus immunotherapy. Transgenes encoded within oncolytic viruses are designed to be highly transcribed, but protein synthesis is often negatively affected by viral infection, compromising the amount of… read more here.
Keywords: hsv1; leader; transgene; oncolytic hsv1 ... See more keywords
Diagnosis and treatment of herpes simplex 1 virus infection in pregnancy
Sign Up to like & getrecommendations! Published in 2017 at "Obstetric Medicine"
DOI: 10.1177/1753495x16689434
Abstract: A nulliparous woman presented at 21 weeks’ gestation with a 72-h history of a rash on her left arm. Initially isolated to the forearm, it had quickly spread, becoming multiple itchy fluid-filled blisters. Blood tests… read more here.
Keywords: hsv1; treatment; infection; herpes simplex ... See more keywords
The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features
Sign Up to like & getrecommendations! Published in 2017 at "Viruses"
DOI: 10.3390/v9020026
Abstract: As one of the major pathogens for human herpetic diseases, herpes simplex virus type 1 (HSV1) causes herpes labialis, genital herpes and herpetic encephalitis. Our aim here was to investigate the infectious process of HSV1… read more here.
Keywords: hsv1; rhesus; infection; pathological features ... See more keywords