Topical application of Hydroxysafflor Yellow A accelerates the wound healing in streptozotocin induced T1DM rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.01.018
Abstract: Abstract To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower, on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in vivo when topically applied to… read more here.
Keywords: topical application; wound healing; hsya; hydroxysafflor yellow ... See more keywords
Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18F‐fuorodeoxyglucose
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.011
Abstract: Abstract Hydroxysafflor yellow A (HSYA) and acetylglutamine (NAG) are extensively applied in the treatment of brain injury. In this study, we investigated the neuroprotective effect and underlying mechanism of HSYA alone or together with NAG… read more here.
Keywords: hsya; cerebral ischemia; effect; hydroxysafflor yellow ... See more keywords
Oral Bioavailability-Enhancing and Anti-obesity Effects of Hydroxysafflor Yellow A in Natural Deep Eutectic Solvent
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00457
Abstract: Hydroxysafflor yellow A (HSYA), a primary active component in Carthami Flos, has been extensively applied in the treatment of cardiometabolic diseases. In this study, a natural deep eutectic solvent composed of glucose and choline chloride… read more here.
Keywords: hsya; deep eutectic; hydroxysafflor yellow; obesity ... See more keywords
Elucidation of the biosynthetic pathway of hydroxysafflor yellow A
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59774-3
Abstract: Hydroxysafflor yellow A (HSYA) is a clinical investigational new drug for the treatment of acute ischemic stroke. It has a unique quinochalcone di-C-glycoside structure and is exclusively found in the flowers of safflower (Carthamus tinctorius).… read more here.
Keywords: biosynthetic pathway; hydroxysafflor yellow; biosynthesis hsya; hsya ... See more keywords
Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2020 at "Mediators of Inflammation"
DOI: 10.1155/2020/2720369
Abstract: Xuebijing injection is a Chinese herb compound to treat sepsis in China, but it contains many different kinds of components, and each component may have different effects in treating sepsis. The present study was performed… read more here.
Keywords: hsya; net release; lung injury; acute lung ... See more keywords
Protective Effect of Hydroxysafflor Yellow A on Nephropathy by Attenuating Oxidative Stress and Inhibiting Apoptosis in Induced Type 2 Diabetes in Rat
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/7805393
Abstract: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and its prevalence has been increasing all over the world, which is also the leading cause of end-stage renal failure. Hydroxysafflor yellow A (HSYA) is… read more here.
Keywords: apoptosis; hydroxysafflor yellow; hsya; oxidative stress ... See more keywords
Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/6643615
Abstract: Myocardial ischemia/reperfusion injury (MI/RI) is an urgent problem with a great impact on health globally. However, its pathological mechanisms have not been fully elucidated. Hydroxysafflor yellow A (HSYA) has a protective effect against MI/RI. This… read more here.
Keywords: hsya; apoptosis; effect; calcium overload ... See more keywords
SUN-684 Anti-Obesity Effects of HSYA through Inducing Lac-Phe and Inhibiting GIP
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvaf149.193
Abstract: Abstract Disclosure: W. Hu: None. K. Yan: None. X. Lyu: None. X. Guo: None. Z. Zhou: None. Y. Zhao: None. L. Wang: None. H. Yang: None. H. Zhu: None. H. Pan: None. Q. Yang: None.… read more here.
Keywords: none; phe; hsya; lac phe ... See more keywords
Hydroxysafflor Yellow A-Induced Osteoblast Differentiation and Proliferation of BM-MSCs by Up-Regulating Nuclear Vitamin D Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524023666220820125924
Abstract: BACKGROUND Vitamin D receptor (VDR) is critical for mineral and bone homeostasis, since it plays an essential role in the osteoblast differentiation of bone marrow mesenchymal stem cells (BM-MSCs). Hydroxysafflor yellow A (HSYA) has the… read more here.
Keywords: hsya; calcium; proliferation; expression ... See more keywords
Hydroxysafflor yellow A ameliorates Toll-like receptor 4-mediated septic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220413130254
Abstract: BACKGROUND Sepsis is a life-threatening condition caused by bacterially-induced systemic inflammation that can result in septic cardiomyopathy. Bacterial lipopolysaccharide (LPS) stimulates the Toll-like receptor 4 (TLR4, Tlr4)-induced inflammatory response and intracellular reactive oxygen species (ROS)… read more here.
Keywords: md2; hsya; toll like; septic cardiomyopathy ... See more keywords
Hydroxy-Safflower Yellow A Alleviates Osteoporosis in Ovariectomized Rat Model by Inhibiting Carbonic Anhydrase 2 Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.734539
Abstract: Background: To investigate the therapeutic effect of Hydroxy-safflower yellow A (HSYA) on rat’s osteoporosis and explore its potential mechanism of action. Methods: Bilateral ovariectomized female rats (OVX) were used to establish a postmenopausal rat model… read more here.
Keywords: safflower yellow; hsya; hydroxy safflower; bone ... See more keywords