Serotonin 5‐HT7 receptor overexpression in the raphe nuclei area produces antidepressive effect and affects brain serotonin system in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25055
Abstract: Heterodimerization between 5‐HT7 and 5‐HT1A receptors seems to play an important role in the mechanism of depression and antidepressant drug action. It was suggested that the shift of the ratio between 5‐HT1A/5‐HT7 hetero‐ and 5‐HT1A/5‐HT1A… read more here.
Keywords: ht7 receptor; ht1a; receptor; receptor overexpression ... See more keywords
Biphasic effects of 5-HT1A agonism on impulsive responding are dissociable from effects on anxiety in the variable consecutive number task
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01684-5
Abstract: The serotonergic 5-HT1A receptor is known to be involved in both impulsivity and anxiety-related behavior. Although anxiety and impulsivity are different constructs, it has been shown that anxiogenesis can result in impulsiveness. It is therefore… read more here.
Keywords: consecutive number; task; anxiety; ht1a ... See more keywords
Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT1A receptor partial agonist activity.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05839-2
Abstract: RATIONALE Preclinical and clinical reports suggest that ferulic acid (FA), a plant-derived phenylpropanoid, is effective against mental health problems such as agitation, anxiety, and irritability in humans, without causing adverse side effects. However, the mechanism… read more here.
Keywords: ht1a receptor; isolation reared; analysis; ht1a ... See more keywords
Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-018-0366-4
Abstract: Traumatic brain injury is a complex phenomenon leading to neurological diseases and persistent disability that currently affects millions of people worldwide. Increasing evidence shows that a wide range of patients with mild traumatic brain injury… read more here.
Keywords: depression; traumatic brain; ht1a; brain injury ... See more keywords
P.1.006 Chronic administration of clozapine increases the level of serotonin 5-HT1A receptor heterodimerisation with 5-HT2A or D2 receptors in the mouse cortex
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.024
Abstract: Background and Aims It is well established that dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receptors play an important role in neurotransmission and that alterations in their functioning are implicated in many psychiatric disorders,… read more here.
Keywords: ht2a receptors; ht1a ht2a; ht1a; receptors mouse ... See more keywords
Role of 5-HT1A in the nucleus of the solitary tract in the regulation of swallowing activities evoked by electroacupuncture in anesthetized rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.06.018
Abstract: Somatic stimulation therapy, such as electroacupuncture (EA), has been widely applied in the clinic to treat dysphagia. However, its underlying mechanism has remained unknown. In the present study, the effect of EA at acupoints Fengfu… read more here.
Keywords: swallowing activities; ht1a nucleus; ht1a; solitary tract ... See more keywords
5-HT1A receptor-mediated activation of neuroendocrine responses and multiple protein kinase pathways in the peripubertal rat hypothalamus
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.07.008
Abstract: ABSTRACT Increasing evidence suggests that multiple factors can produce effects on the immature brain that are distinct and more long‐lasting than those produced in adults. The hypothalamic paraventricular nucleus (PVN) is a region integral to… read more here.
Keywords: peripubertal rat; ht1a receptor; kinase; neuroendocrine responses ... See more keywords
NLX-112, a highly selective 5-HT1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.109025
Abstract: NLX-112 (a.k.a. F13640 or befiradol) exhibits nanomolar affinity, exceptional selectivity and biased agonism at serotonin 5-HT1A receptors. NLX-112 displays robust analgesic activity in a number of rodent models of pain, and is currently developed as… read more here.
Keywords: misuse potential; ht1a; nlx 112; icss ... See more keywords
The 5-HT1A receptor as a serotonergic target for neuroprotection in cerebral ischemia
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110210
Abstract: Cerebral ischemia due to stroke or cardiac arrest greatly affects daily functioning and the quality of life of patients and has a high socioeconomic impact due to the surge in their prevalence. Advances in the… read more here.
Keywords: cerebral ischemia; ht1a receptor; ht1a; neuroprotection cerebral ... See more keywords
Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00638
Abstract: The serotonin 1A receptor (5-HT1A) system has been extensively implicated in modulating mood and behavior. Notably, 5-HT1A levels in humans display remarkable variation, and differences in receptor levels have been linked with a variety of… read more here.
Keywords: single nucleotide; ht1a; rs6295; nucleotide polymorphism ... See more keywords
Existence of Brain 5-HT1A–5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor–Receptor Interactions Regulating 5-HT1A Receptor Recognition
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b00629
Abstract: Studies on serotonin-selective reuptake inhibitors have established that disturbances in the ascending 5-HT neuron systems and their 5-HT receptor subtypes and collateral networks to the forebrain contribute to the etiology of major depression and are… read more here.
Keywords: receptor; ht1a ht2a; ht1a; ht2a isoreceptor ... See more keywords