Improvement of urethral dysfunction by 5‐HT1A receptor agonist NLX‐112 in diabetic rats
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DOI: 10.1002/nau.24993
Abstract: To examine the effects of the selective 5‐HT1A receptor agonist, NLX‐112, on urethral function in streptozotocin‐induced diabetic rats. read more here.
Keywords: diabetic rats; agonist nlx; ht1a receptor; nlx 112 ... See more keywords
Effects of 5-HT2C, 5-HT1A receptor challenges and modafinil on the initiation and persistence of gambling behaviours
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DOI: 10.1007/s00213-020-05496-x
Abstract: Problematic patterns of gambling are characterised by loss of control and persistent gambling often to recover losses. However, little is known about the mechanisms that mediate initial choices to begin gambling and then continue to… read more here.
Keywords: ht1a receptor; challenges modafinil; receptor challenges; effects ht2c ... See more keywords
Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT1A receptor partial agonist activity.
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DOI: 10.1007/s00213-021-05839-2
Abstract: RATIONALE Preclinical and clinical reports suggest that ferulic acid (FA), a plant-derived phenylpropanoid, is effective against mental health problems such as agitation, anxiety, and irritability in humans, without causing adverse side effects. However, the mechanism… read more here.
Keywords: ht1a receptor; isolation reared; analysis; ht1a ... See more keywords
Bell-shaped agonist activation of 5-HT1A receptor-coupled Gαi3 G-proteins: Receptor density-dependent switch in receptor signaling.
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DOI: 10.1016/j.cellsig.2019.109383
Abstract: A previous study observed bell-shaped concentration-response isotherms for activation of Gαi3 G-protein subunits by high efficacy 5-HT1A receptor agonists in a Chinese hamster ovary (CHO) cell line expressing high levels of these receptors. This suggested… read more here.
Keywords: ht1a receptor; activation; receptor; bell shaped ... See more keywords
The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.026
Abstract: N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine (3) is a potent 5-HT1A receptor and α1d-adrenoceptor (α1d-AR) ligand. Analogues 5-10 were rationally designed and prepared to evaluate whether electronic and/or lipophilic properties of substituents in the ortho position of its phenoxy moiety… read more here.
Keywords: ht1a receptor; dioxan methyl; diphenyl dioxan; receptor ... See more keywords
Preparation and characterization of immobilized 5-HT1A receptor stationary phase for high throughput screening of the receptor-binding ligands from complex systems like Curcuma wenyujin Y. H. Chen et C. Ling extract
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DOI: 10.1016/j.jpba.2022.114632
Abstract: The incidence of depression has increased significantly during the COVID-19 pandemic. This disease is closely associated with serotonin 1A (5-HT1A) receptor and often treated by complex prescription containing Curcuma wenyujin Y. H. Chen et C.… read more here.
Keywords: curcuma wenyujin; chen ling; immobilized ht1a; ht1a receptor ... See more keywords
Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain
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DOI: 10.1016/j.neuropharm.2017.07.022
Abstract: BACKGROUND AND PURPOSE NLX-112 (a.k.a. befiradol, F13640) is a drug candidate intended for the treatment of l-DOPA-induced dyskinesia. It is a highly selective serotonin 5-HT1A receptor full agonist which has been previously tested in a… read more here.
Keywords: nlx 112; mouse models; ht1a receptor; pain ... See more keywords
5-HT1A receptor-mediated activation of neuroendocrine responses and multiple protein kinase pathways in the peripubertal rat hypothalamus
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DOI: 10.1016/j.neuropharm.2018.07.008
Abstract: ABSTRACT Increasing evidence suggests that multiple factors can produce effects on the immature brain that are distinct and more long‐lasting than those produced in adults. The hypothalamic paraventricular nucleus (PVN) is a region integral to… read more here.
Keywords: peripubertal rat; ht1a receptor; kinase; neuroendocrine responses ... See more keywords
Behavior of Adult 5-HT1A Receptor Knockout Mice Exposed to Stress During Prenatal Development
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DOI: 10.1016/j.neuroscience.2017.11.039
Abstract: Chronic maternal stress during pregnancy can have long-term, detrimental consequences for the offspring. An understanding of the mechanisms responsible for mediating these effects is essential for devising therapeutic interventions. Here, we examined whether serotonin 1A… read more here.
Keywords: prenatal stress; ht1a receptor; stress; mice ... See more keywords
Hippocampal and Septal 5-HT1A Receptor Expression in Two Rat Models of Temporal Lobe Epilepsy
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DOI: 10.1016/j.neuroscience.2021.03.026
Abstract: Experimental and clinical data suggest an impact of serotonergic signaling on seizure susceptibility and epilepsy-associated psychiatric comorbidities. Previous µPET studies revealed increased binding of 5-HT1A receptor ligand [18F]MPPF in two rat models with spontaneous recurrent… read more here.
Keywords: receptor; ht1a receptor; receptor expression; rat ... See more keywords
Administration of low doses of the 5-HT1A receptor agonist 8-OH-DPAT attenuates the discriminative signal of amphetamine in the conditioned taste aversion procedure
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DOI: 10.1016/j.pbb.2020.172932
Abstract: Several studies have reported that low doses of the 5-HT1A receptor agonist 8-OH-DPAT reduce cocaine-induced locomotor activity. However, it has also been reported that high doses of 8-OH-DPAT do not substitute for or alter the… read more here.
Keywords: dpat; doses ht1a; ht1a receptor; discriminative signal ... See more keywords