Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173589
Abstract: Neferine, a bisbenzylisoquinoline alkaloid present in Nelumbo nucifera, has been reported to exhibit neuroprotective effects. Because reduced glutamatergic transmission through inhibition of glutamate release has been proposed as a mechanism of neuroprotection, we investigated whether… read more here.
Keywords: inhibits glutamate; glutamate release; ht1a receptors; neferine bisbenzylisoquinoline ... See more keywords
Key role of 5‐HT1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys
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DOI: 10.1111/ejn.14769
Abstract: In mammals, 5‐HTexcitatory respiratory effects imply 5‐HT1A receptor‐mediated disinhibition of pre‐Bötzinger complex neurons. In the lamprey, 5‐HT1A receptors are involved in the neural control of locomotion, but their role in the respiratory regulation, particularly at… read more here.
Keywords: ht1a receptor; respiratory rhythm; ht1a; ht1a receptors ... See more keywords
Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats
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DOI: 10.1159/000505212
Abstract: Background: Depression is one of the most common neuropsychiatric disturbances in Parkinson’s disease (PD), but its pathophysiology is not definite. Lines of evidence have indicated that the hippocampus and serotonin 1A (5-HT1A) receptors are related… read more here.
Keywords: depression; dorsal hippocampus; ht1a; ht1a receptors ... See more keywords
Tandospirone prevents stress-induced anxiety-like behavior and visceral hypersensitivity by suppressing theta oscillation enhancement via 5-HT1A receptors in the anterior cingulate cortex in rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.922750
Abstract: Tandospirone, a third-generation of antianxiety agent with fewer side effects, has been widely used in the treatment of anxiety. Moreover, it is interesting that tandospirone has been found to relieve gastrointestinal symptoms in patients with… read more here.
Keywords: stress; anxiety like; visceral hypersensitivity; ht1a receptors ... See more keywords
Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK1/2 and p38) Activation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072350
Abstract: The importance of the dynamic interplay between the opioid and the serotonin neuromodulatory systems in chronic pain is well recognized. In this study, we investigated whether these two signalling pathways can be integrated at the… read more here.
Keywords: peptide opioids; ht1a receptors; opioid mop; mop serotonin ... See more keywords
Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors
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DOI: 10.3390/ph14080744
Abstract: The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates to fulfill these criteria.… read more here.
Keywords: methoxyphenylpiperazine derivative; novel methoxyphenylpiperazine; ht1a receptors; antidepressant like ... See more keywords