Effect of sumatriptan on acetic acid-induced experimental colitis in rats: a possible role for the 5-HT1B/1D receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Naunyn-Schmiedeberg's archives of pharmacology"
DOI: 10.1007/s00210-022-02215-5
Abstract: Mucosal inflammation in colitis is associated with changes in the intestinal serotonin (5-HT) level. Sumatriptan, a 5-HT1B/1D receptor agonist, has demonstrated anti-inflammatory characteristics. The purpose of this study was to determine the effects of sumatriptan… read more here.
Keywords: experimental colitis; colitis; ht1b receptors; acetic acid ... See more keywords
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113870
Abstract: The 5-HT1A and 5-HT1B serotonin receptors are abundantly expressed in the CNS and constitute validated as well as putative drug targets in a variety of psychiatric and cognitive disorders, alcoholism/addiction, pain and migraine. In the… read more here.
Keywords: ht1a ht1b; fluorescence; protein activated; ht1b serotonin ... See more keywords
Binding Interactions of Ergotamine and Dihydroergotamine to 5-Hydroxytryptamine Receptor 1B (5-HT1b) Using Molecular Dynamics Simulations and Dynamic Network Analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b01082
Abstract: Ergotamine (ERG) and dihydroergotamine (DHE), common migraine drugs, have small structural differences, but leading to clinically important distinctions in their pharmacological profiles. For example, DHE is less potent than ERG by about ten-fold at the… read more here.
Keywords: molecular dynamics; receptor ht1b; analysis; ht1b ... See more keywords
Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity
Sign Up to like & getrecommendations! Published in 2019 at "EJNMMI Research"
DOI: 10.1186/s13550-019-0570-1
Abstract: BackgroundOver the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist… read more here.
Keywords: pet; affinity; ht1b; intrinsic activity ... See more keywords