Silencing of circFoxO3 Protects HT22 Cells from Glutamate-Induced Oxidative Injury via Regulating the Mitochondrial Apoptosis Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00817-2
Abstract: Recent studies demonstrated that FoxO3 circular RNA (circFoxO3) plays an important regulatory role in tumourigenesis and cardiomyopathy. However, the role of circFoxO3 in neurodegenerative diseases remains unknown. The aim of this study was to examine… read more here.
Keywords: circfoxo3; cells glutamate; glutamate induced; induced oxidative ... See more keywords
N2L, a novel lipoic acid-niacin dimer protects HT22 cells against β-amyloid peptide-induced damage through attenuating apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00482-5
Abstract: β-amyloid protein (Aβ) is thought to be the primary cause of the pathogenesis of Alzheimer’s disease (AD). Niacin has been reported to have beneficial effects on AD. Previously, we synthesized a novel compound lipoicacid–niacin dimer… read more here.
Keywords: apoptosis; n2l novel; niacin dimer; ht22 cells ... See more keywords
The Thiol-Modifier Effects of Organoselenium Compounds and Their Cytoprotective Actions in Neuronal Cells
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03026-x
Abstract: Most pharmacological studies concerning the beneficial effects of organoselenium compounds have focused on their ability to mimic glutathione peroxidase (GPx). However, mechanisms other than GPx-like activity might be involved on their biological effects. This study… read more here.
Keywords: mrk picolyl; ht22 cells; organoselenium compounds; effects organoselenium ... See more keywords
Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.064
Abstract: Amyloid beta (Aβ) is the main component of the amyloid plaques that accumulate in the brains of Alzheimer patients. Here, we reported the protective role of Formononetin (Form) against Aβ25-35-induced neurotoxicity in HT22 cells. We… read more here.
Keywords: ht22; akt signaling; pi3k akt; ht22 cells ... See more keywords
Ephrin-B2 inhibits Aβ25-35-induced apoptosis by alleviating endoplasmic reticulum stress and promoting autophagy in HT22 cells
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.028
Abstract: Previous studies have shown that Erythropoietin-producing hepatocellular carcinoma receptor B2 (EphB2) inhibited Aβ-induced neuron apoptosis and improved cognition in AD mice, but the role of which ligand Ephrin B2 (Ephrin-B2, efnB2) is not clear. The… read more here.
Keywords: ht22; apoptosis; ht22 cells; stress ... See more keywords
Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105973
Abstract: The purpose of our study is to determine the protective effects of mitophagy enhancers against phosphorylated tau (P-tau)-induced mitochondrial and synaptic toxicities in Alzheimer's disease (AD). Mitochondrial abnormalities, including defective mitochondrial dynamics, biogenesis, axonal transport… read more here.
Keywords: tau; ht22 cells; mitophagy enhancers; mitophagy ... See more keywords
Aconitine induces cell apoptosis via mitochondria and death receptor signaling pathways in hippocampus cell line.
Sign Up to like & getrecommendations! Published in 2022 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2022.01.001
Abstract: Aconitine is a plant toxin derived from aconitum genus and well known for its neurological and vascular toxicity. However, the mechanism of toxicity on the growth and apoptosis of the neurological cells has not been… read more here.
Keywords: receptor signaling; signaling pathways; apoptosis; aconitine ... See more keywords
The protective effect of trilobatin against isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells involves the Nrf2/ARE pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152537
Abstract: Long-term exposure to isoflurane may induce long-term developmental neurotoxicity and cognitive impairments in the neonatal brains. Trilobatin, a leaf extract from the Chinese traditional sweet tea Lithocarpus polystachyus Rehd, possesses various biological properties including anti-inflammatory… read more here.
Keywords: ht22 cells; isoflurane induced; neurotoxicity; trilobatin ... See more keywords
Formaldehyde induces ferroptosis in hippocampal neuronal cells by upregulation of the Warburg effect.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152650
Abstract: The mechanisms underlying formaldehyde (FA)-induced neurotoxicity have not yet been fully clarified. Ferroptosis is a novel regulatory cell death and the Warburg effect is involved in regulating neural function. In this study, we investigated whether… read more here.
Keywords: induces ferroptosis; ht22 cells; warburg effect; effect ... See more keywords
Role of Autophagy Mediated by AMPK/DDiT4/mTOR Axis in HT22 Cells Under Oxygen and Glucose Deprivation/Reoxygenation
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07280
Abstract: Background: cerebral ischemia/reperfusion (I/R) injury is an important complication of ischemic stroke, and autophagy is one of the mechanisms of it. In this study, we aimed to determine the role and mechanism of autophagy in… read more here.
Keywords: ampk ddit4; ddit4 mtor; ht22 cells; mtor ... See more keywords
Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1773821
Abstract: Abstract Objective To explore the role of protease nexin-1 (PN-1) in Alzheimer’s disease (AD) via the sonic hedgehog (SHH) pathway. Methods PN-1 lentiviral activation particles were injected into APP/PS1 transgenic AD and wild-type (WT) mice;… read more here.
Keywords: alzheimer disease; ht22 cells; protease nexin; shh pathway ... See more keywords