Role of prefrontal cortical 5-HT2A receptors and serotonin transporter in the behavioral deficits in post-pubertal rats following neonatal lesion of the ventral hippocampus
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112226
Abstract: Neonatal ventral hippocampal-lesioned (NVHL) rats have been shown to display neurochemical and behavioral abnormalities at adulthood, analogous to some of those seen in schizophrenia. Serotonergic neurotransmission is implicated the pathophysiology and treatment of schizophrenia. In… read more here.
Keywords: ht2a; post pubertal; pubertal nvhl; nvhl rats ... See more keywords
Estrogen receptor β deficiency impairs BDNF–5-HT2A signaling in the hippocampus of female brain: A possible mechanism for menopausal depression
Sign Up to like & getrecommendations! Published in 2017 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2017.05.016
Abstract: Depression currently affects 350 million people worldwide and 19 million Americans each year. Women are 2.5 times more likely to experience major depression than men, with some women appearing to be at a heightened risk… read more here.
Keywords: depression; ht2a; bdnf ht2a; estrogen ... See more keywords
5-HT2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2017.06.001
Abstract: Chronic stress enhances risk for psychiatric disorders, and in animal models is known to evoke depression-like behavior accompanied by perturbed neurohormonal, metabolic, neuroarchitectural and transcriptional changes. Serotonergic neurotransmission, including serotonin2A (5-HT2A) receptors, have been implicated… read more here.
Keywords: ht2a; unpredictable stress; chronic unpredictable; ht2a receptor ... See more keywords
Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00597
Abstract: Ariadne is a non-hallucinogenic analog in the phenylalkylamine chemical class of psychedelics that is closely related to an established synthetic hallucinogen, 2,5-dimethoxy-4-methyl-amphetamine (DOM), differing only by one methylene group in the α-position to the amine.… read more here.
Keywords: pharmacology; ariadne analogs; non hallucinogenic; ht2a ... See more keywords
LSD-induced increases in social adaptation to opinions similar to one’s own are associated with stimulation of serotonin receptors
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68899-y
Abstract: Adapting one’s attitudes and behaviors to group norms is essential for successful social interaction and, thus, participation in society. Yet, despite its importance for societal and individual functioning, the underlying neuropharmacology is poorly understood. We… read more here.
Keywords: increases social; ht2a; lsd induced; adaptation opinions ... See more keywords
Psychedelics: Old drugs, new trips
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811211003495
Abstract: This special edition of the Journal of Psychopharmacology continues a reflection of psychopharmacology’s vogue to breathe new life into old drugs. The shimmer of psychedelia is back from the grave of legal prohibition, seemingly to… read more here.
Keywords: old drugs; ht2a; psychedelics old; psychopharmacology ... See more keywords
Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs
Sign Up to like & getrecommendations! Published in 2018 at "eNeuro"
DOI: 10.1523/eneuro.0220-18.2018
Abstract: Abstract GPCRs such as 5-HT2A and D2 are implicated in the therapeutic and the side effects of antipsychotics. However, the pattern of brain activity that leads to the behavioral effects of antipsychotics is poorly understood.… read more here.
Keywords: atypical antipsychotics; ht2a; cellular correlates; identifying vivo ... See more keywords
Prepulse inhibition of the acoustic startle reflex impairment by 5-HT2A receptor activation in the inferior colliculus is prevented by GABAA receptor blockade in the pedunculopontine tegmental nucleus
Sign Up to like & getrecommendations! Published in 2023 at "Behavioural Brain Research"
DOI: 10.2139/ssrn.4309315
Abstract: The relationship between serotonin dysfunction and schizophrenia commenced with the discovery of the effects of lysergic acid diethylamide (LSD) that has high affinity for 5-HT2A receptors. Activation of these receptors produces perceptual and behavioural changes… read more here.
Keywords: ht2a; doi; inferior colliculus; prepulse inhibition ... See more keywords
Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00040
Abstract: G-protein–coupled receptor (GPCR) heterodimers are new targets for the treatment of schizophrenia. Dopamine D2 receptors and serotonin 5-HT1A and 5-HT2A receptors play an important role in neurotransmission and have been implicated in many human psychiatric… read more here.
Keywords: ht1a ht2a; ht2a; ht1a; dopamine receptors ... See more keywords
Editorial: Pharmacology of new psychoactive substances
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1208957
Abstract: Several classes of novel psychoactive substances have been introduced in illicit markets throughout the world and more are being developed. They present major law enforcement challenges and global public health threats. However, there is limited… read more here.
Keywords: ht2a; psychoactive substances; pharmacology; ht2b receptor ... See more keywords