Synthesis and Evaluation of Novel Aza-Aromatics as Dual 5-HT2A and 5-HT2C Receptor Agonists
Sign Up to like & getrecommendations! Published in 2025 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.5c00505
Abstract: The 5-HT2A and 5-HT2C receptors are key therapeutic targets for CNS disorders. We investigated whether a nonhallucinogenic dual 5-HT2A/5-HT2C agonist could offer novel treatment potential. Large screening of in-house structurally diverse compounds revealed centhaquin, an… read more here.
Keywords: evaluation novel; ht2c; ht2a ht2c; synthesis evaluation ... See more keywords
Serotonin 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2025.1639344
Abstract: Introduction Studies suggest that serotonin (5-HT) plays an important role in alcohol use disorder (AUD). While several receptor subtypes modulate the role of 5-HT in AUD, evidence suggests that 5-HT2A and 5-HT2C receptors may be… read more here.
Keywords: ht2a ht2c; alcohol drinking; acquisition; alcohol ... See more keywords