PM2.5 upregulates rat mesenteric arteries 5‐HT2A receptor via inflammatory‐mediated mitogen‐activated protein kinases signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Toxicology"
DOI: 10.1002/tox.22810
Abstract: Fine particulate matter (PM2.5) is an important environmental risk factor for cardiovascular diseases. However, little is known about the effects of PM2.5 on arteries. The present study investigated whether PM2.5 alters 5‐hydroxytryptamine (5‐HT) receptor expression… read more here.
Keywords: protein; pm2; ht2a receptor; expression ... See more keywords
Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on l-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Brain Research"
DOI: 10.1007/s00221-018-5390-4
Abstract: Abstractl-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapy for motor symptoms of Parkinson’s disease (PD); however, with repeated administration, as many as 94% of PD patients develop complications such as l-DOPA-induced dyskinesia. We previously demonstrated that… read more here.
Keywords: 014 dopa; emd 281; ht2a receptor; dopa induced ... See more keywords
5-HT2A receptor deficiency alters the metabolic and transcriptional, but not the behavioral, consequences of chronic unpredictable stress
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2017.06.001
Abstract: Chronic stress enhances risk for psychiatric disorders, and in animal models is known to evoke depression-like behavior accompanied by perturbed neurohormonal, metabolic, neuroarchitectural and transcriptional changes. Serotonergic neurotransmission, including serotonin2A (5-HT2A) receptors, have been implicated… read more here.
Keywords: ht2a; unpredictable stress; chronic unpredictable; ht2a receptor ... See more keywords
Revealing the interaction modes of 5-HT2A receptor antagonists and the Structure-Based virtual screening from FDA and TCMNP database
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1768900
Abstract: Abstract 5-hydroxytryptamine 2A (5-HT2A) receptor is emerging as an important target for numerous psychoactive drugs due to its imperative roles in psychological diseases. In fact, multiple 5-HT2A receptor antagonists were developed to treat numerous psychiatric… read more here.
Keywords: ht2a receptor; structure; receptor; receptor antagonists ... See more keywords
Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlad030
Abstract: The sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality in the United States, is typically associated with a sleep period. Previously, we showed evidence of serotonergic abnormalities in the medulla (e.g.… read more here.
Keywords: receptor binding; sudden infant; part; infant death ... See more keywords
Glucosylsphingosine evokes pruritus via activation of 5-HT2A receptor and TRPV4 in sensory neurons.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15733
Abstract: BACKGROUND AND PURPOSE Glucosylsphingosine (GS), an endogenous sphingolipid, is highly accumulated in the epidermis of patients with atopic dermatitis (AD) due to abnormal ceramide metabolism. More importantly, GS can evoke scratching behaviors. However, the precise… read more here.
Keywords: receptor; receptor trpv4; sensory neurons; ht2a receptor ... See more keywords
Spinal 5-HT2A receptor is involved in electroacupuncture inhibition of chronic pain
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pain"
DOI: 10.1177/17448069221087583
Abstract: Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, and it is a typical disease which can develop chronic pain. Our previous study has proved that endocannabinoid (2-AG)-CB1R-GABA-5-HT pathway is involved in electroacupuncture (EA)… read more here.
Keywords: chronic pain; pain; inhibition chronic; receptor ... See more keywords
Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions
Sign Up to like & getrecommendations! Published in 2019 at "EJNMMI Research"
DOI: 10.1186/s13550-019-0527-4
Abstract: BackgroundCimbi-36 can be 11C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT2A receptor in the brain. In its non-labeled form (25B-NBOMe), it is used as a recreational drug… read more here.
Keywords: cimbi; biodistribution; ht2a receptor; dosimetry ... See more keywords
Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.930346
Abstract: Various forms of traumatic brain injury (TBI) are a leading cause of disability in the United States, with the generation of neuropsychiatric complications such as depression, anxiety, social dysfunction, and suicidality being common comorbidities. Serotonin… read more here.
Keywords: receptor signaling; mild tbi; receptor; deficits social ... See more keywords
Sex Differences in Animal Models of Sodium-Valproate-Induced Autism in Postnatal BALB/c Mice: Whole-Brain Histoarchitecture and 5-HT2A Receptor Biomarker Evidence
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11010079
Abstract: Simple Summary Valproic acid (VPA) is a well-known antiepileptic medication and mood stabiliser that is frequently prescribed for the treatment of epilepsy, particularly in children, and has proven human teratogenic activity. VPA inhibits histone deacetylase,… read more here.
Keywords: balb mice; autism; vpa; induced autism ... See more keywords