Development of Pharmacophore Models for the Important Off-Target 5-HT2B Receptor.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01679
Abstract: Toxicity is a major cause of attrition in the development of pharmaceuticals, and the off-target effects are a frequent contributor. The 5-HT2B receptor agonism is known to be responsible for a variety of safety concerns… read more here.
Keywords: ht2b; pharmacophore models; ht2b receptor; development ... See more keywords
Serotonin 2B Receptor by Interacting with NMDA Receptor and CIPP Protein Complex May Control Structural Plasticity at Glutamatergic Synapses.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00638
Abstract: The serotonin 2B (5-HT2B) receptor coupled to Gq-protein contributes to the control of neuronal excitability and is implicated in various psychiatric disorders. The mechanisms underlying its brain function are not fully described. Using peptide affinity… read more here.
Keywords: receptor; ht2b receptor; receptor cipp; nmda receptor ... See more keywords
Editorial: Pharmacology of new psychoactive substances
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1208957
Abstract: Several classes of novel psychoactive substances have been introduced in illicit markets throughout the world and more are being developed. They present major law enforcement challenges and global public health threats. However, there is limited… read more here.
Keywords: ht2a; psychoactive substances; pharmacology; ht2b receptor ... See more keywords