Synthesis and Evaluation of Pyridyloxypyridyl Indole Carboxamides as Potential PET Imaging Agents for 5-HT2C Receptors.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00443
Abstract: Nine pyridyloxypyridyl indole carboxamides were synthesized and displayed high affinities for 5-HT2C receptors and high selectivity over 5-HT2A and 5-HT2B. Among them, 6-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]1H-indole-3-carboxamide (8) exhibits the highest 5-HT2C binding affinity (Ki = 1.3 nM) and… read more here.
Keywords: ht2c receptors; indole carboxamides; evaluation pyridyloxypyridyl; carboxamides potential ... See more keywords
Anxiolytic-Like Effects of Extremely Low Frequency Electric Field in Stressed Rats: Involvement of 5-HT2C Receptors.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of radiation biology"
DOI: 10.1080/09553002.2022.2087929
Abstract: BACKGROUND Possible modulatory effects of non-invasive brain stimulation have gained interest recently. In our study, the effect of low frequency electric fields (LF-EF) on stress-induced electrophysiological, behavioral changes and the possible involvement of serotonergic 5-HT2C… read more here.
Keywords: ht2c receptor; low frequency; frequency electric; ht2c receptors ... See more keywords