SR 57227A is a partial agonist/partial antagonist of 5-HT3 receptor and inhibits subsequent 5-HT- or SR 57227A-induced 5-HT3 receptor current.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.174
Abstract: The serotonin (5-hydroxytryptamine) type 3 (5-HT3) receptors are transmembrane ligand-gated ion channels. Although several 5-HT3 receptor agonists have been used as preclinical tools, SR 57227A is the most commonly used 5-HT3 receptor agonist with the… read more here.
Keywords: agonist partial; partial antagonist; ht3 receptor; receptor ... See more keywords
Colitis-induced alterations in response properties of visceral nociceptive neurons in the rat caudal medulla oblongata and their modulation by 5-HT3 receptor blockade
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.07.013
Abstract: There is considerable clinical and experimental evidence that intestinal inflammation is associated with altered visceral nociceptive processing in the spinal cord and brain, but the underlying neuronal mechanisms, especially acting at the supraspinal level, remain… read more here.
Keywords: colitis; crd; ht3 receptor; visceral nociceptive ... See more keywords
The 5-HT3 receptor antagonist ondansetron potentiates the effects of the acetylcholinesterase inhibitor donepezil on neuronal network oscillations in the rat dorsal hippocampus
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.09.017
Abstract: ABSTRACT Cognitive impairments in Alzheimer's disease (AD) have been associated with alterations in neuronal oscillatory activity, of which hippocampal theta and gamma oscillations are essential for the coordination of neuronal networks during cognitive functions. Cognitive… read more here.
Keywords: ondansetron potentiates; ht3 receptor; potentiates effects; theta gamma ... See more keywords
Anticonvulsant Effect of Minocycline on Pentylenetetrazole-Induced Seizure in Mice: Involvement of 5-HT3 Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1783-7836
Abstract: Minocycline, widely used as an antibiotic, has recently been found to have an anti-inflammatory, neuroprotective and anticonvulsant effects. This study was aimed to investigate the anticonvulsant effect of acute administration of minocycline on pentylenetetrazole (PTZ)-induced… read more here.
Keywords: ht3 receptor; anticonvulsant effect; effect; minocycline ... See more keywords
An overview of 5-HT3 receptor antagonists as a treatment option for irritable bowel syndrome with diarrhea.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on pharmacotherapy"
DOI: 10.1080/14656566.2023.2214314
Abstract: INTRODUCTION Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain, discomfort, and altered bowel habits, which affects the quality of life of approximately 10% of the worldwide population. IBS is classified… read more here.
Keywords: ht3; ht3 receptor; treatment; irritable bowel ... See more keywords
Effects of 5‐HT₃ receptor antagonists on cisplatin‐induced kidney injury
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Science"
DOI: 10.1111/cts.13045
Abstract: Nausea, vomiting, and renal injury are the common adverse effects associated with cisplatin. Cisplatin is excreted via the multidrug and toxin release (MATE) transporter, and the involvement of the MATE transporter in cisplatin‐induced kidney injury… read more here.
Keywords: kidney injury; ht3 receptor; cisplatin induced; receptor antagonists ... See more keywords
Synthesis and Development of Indole Based 5-HT3 Receptor Antagonists as Anti-Emetic Drugs in Oncology: An Update.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210708091134
Abstract: An important group of anti-emetic drugs used in the treatment of nausea and vomiting after chemotherapy contains an indole moiety in their structures, working as 5-hydroxytryptamine type 3 serotonin receptor antagonist (5-HT3). This revision is… read more here.
Keywords: anti emetic; ht3 receptor; emetic drugs; oncology ... See more keywords
Potential Roles of 5-HT3 Receptor Antagonists in Reducing Chemotherapy-Induced Peripheral Neuropathy (CIPN).
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220512122525
Abstract: 5-HT3 receptor antagonists corresponding to ondansetron, granisetron, tropisetron, and palonosetron are clinically accustomed to treat nausea and emesis in chemotherapy patients. However, current and previous studies revealed novel potentials of those ligands in other diseases… read more here.
Keywords: receptor antagonists; roles ht3; ht3 receptor; receptor ... See more keywords
5-HT3 Receptors on Mitochondria Influence Mitochondrial Function
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098301
Abstract: The 5-hydroxytryptamine 3 (5-HT3) receptor belongs to the pentameric ligand-gated cation channel superfamily. Humans have five different 5-HT3 receptor subunits: A to E. The 5-HT3 receptors are located on the cell membrane, but a previous… read more here.
Keywords: ht3 receptors; ht3; mitochondrial function; microscopy ... See more keywords