The 5-HT4 receptor-mediated inhibition of visceral nociceptive neurons in the rat caudal ventrolateral medulla
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.07.039
Abstract: Activation of the serotonin type 4 (5-HT4) receptors has been reported to improve abdominal pain in patients with functional gastrointestinal disorders and reduce visceral nociception in animal models. Earlier studies have proposed that 5-HT4 agonist… read more here.
Keywords: caudal ventrolateral; ht4 receptor; ht4; ventrolateral medulla ... See more keywords
Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01568-4
Abstract: Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal studies 5-HT4 receptor agonists enhance hippocampal-dependent… read more here.
Keywords: ht4 receptor; dependent memory; agonist prucalopride; receptor ... See more keywords
Possible association of 5‐HT4 receptor agonist prucalopride in a 52‐year‐old man with an index manic episode
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DOI: 10.1111/bdi.13245
Abstract: Prucalopride is a selective 5-hydroxytryptamine type 4 (5-HT4) receptor agonist approved for chronic idiopathic constipation in adults. Here, we report a first lifetime episode of acute mania in a 52-year-old man and hypothesize that recent… read more here.
Keywords: old man; year old; receptor agonist; ht4 receptor ... See more keywords
The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons
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DOI: 10.1242/jcs.249193
Abstract: ABSTRACT Morphological remodeling of dendritic spines is critically involved in memory formation and depends on adhesion molecules. Serotonin receptors are also implicated in this remodeling, though the underlying mechanisms remain enigmatic. Here, we uncovered a… read more here.
Keywords: ht4 receptor; adhesion; receptor; adhesion molecule ... See more keywords